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Co-sensitizations to Gibberellin Regulated Proteins (GRPs) in Italy: results of a polycentric study.
Villalta, D; Visentini, D; Pesente, F; Grossi, V; Macchia, D; Cecchi, L; Scala, E; Barrale, M; Onida, R; Brusca, I.
Afiliación
  • Villalta D; Immunology and Allergology Unit, S. Maria degli Angeli Hospital, Pordenone, Italy.
  • Visentini D; Institute of Clinical Pathology, Azienda Sanitaria-Universitaria Friuli Centrale, Udine, Itay.
  • Pesente F; Institute of Clinical Pathology, Azienda Sanitaria-Universitaria Friuli Centrale, Udine, Itay.
  • Grossi V; Immunology and Allergy Laboratory Unit, San Giovanni di Dio Hospital, USL Toscana Centro, Florence, Italy.
  • Macchia D; SOS Allergology Clinical Immunology, San Giovanni di Dio Hospital, Florence, Italy.
  • Cecchi L; SOS Allergy and Clinical Immunology, Ospedale S. Stefano, USL Toscana Centro, Prato, Italy.
  • Scala E; Fondazione Luigi Maria Monti, IDI-IRCCS, Rome, Italy.
  • Barrale M; Clinical Pathology U.O.C., Buccheri La Ferla F.B.F. Hospital, Palermo, Italy.
  • Onida R; Clinical Pathology U.O.C., Buccheri La Ferla F.B.F. Hospital, Palermo, Italy.
  • Brusca I; Clinical Pathology U.O.C., Buccheri La Ferla F.B.F. Hospital, Palermo, Italy.
Eur Ann Allergy Clin Immunol ; 2024 Aug 02.
Article en En | MEDLINE | ID: mdl-39092795
ABSTRACT

Summary:

Background. Gibberellin Regulated Proteins (GRPs) are small glycoproteins that induce allergy to various types of fruit. This study aimed to evaluate co-sensitization to cypress pollen and other molecules responsible for fruit allergy, such as nsLTP (Pru p 3), PR-10 (Bet v1), and Profilin (Bet v2). Methods. Sixty subjects sensitized to peach GRP (Pru p 7) were consecutively recruited from four Italian centers 28 males and 32 females (mean age 37.9 years; range 11-79). Specific IgE for Pru p 7, Pru p 3, Bet v 1, Bet v 2, cypress pollen extract (Cup s), and Cup a 1 were determined in all subjects. Results. Sensitization rates to Cup s, Cup a 1, Pru p 3, Bet v 1, and Bet v 2 in the entire studied population were 90.0%, 83.3%, 45.8%, 40.0%, and 30.0%, respectively. In subjects residing in Northern Italy, the respective sensitization rates were 96.4%, 80.0%, 50.0%, 73.3%, and 40.0%, while in those residing in Southern Italy, they were 83.3%, 86.7%, 40.0%, 6.7%, and 20.0%. The only significant difference was observed for PR-10 (p less than 0.0001) Co-sensitization to PR-10 was found to be associated with a reduced risk of anaphylaxis (OR 0.125). Allergic reactions were most commonly triggered by peach (26/40), followed by orange (12/40), with other foods being less frequently implicated. Conclusions. This study confirms a high association between sensitization to Pru p 7 and cypress pollen and highlights a high percentage of co-sensitization to nsLTP, PR-10, and profilin. PR-10 emerged as a protective factor against anaphylaxis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Eur Ann Allergy Clin Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Italia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Eur Ann Allergy Clin Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Italia