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The clinicopathological significance and prognostic value of PD-L1 in oral squamous cell carcinoma.
Li, Yizhan; Ren, Wenhao; Li, Shaoming; Zheng, Jingjing; Gu, Haiyan; Gao, Ling; Zhi, Keqian.
Afiliación
  • Li Y; Department of Oral and Maxillofacial Reconstruction, The Affiliated Hospital of Qingdao University, Qingdao, China.
  • Ren W; School of Stomatology, Qingdao University, Qingdao, China.
  • Li S; Key Lab of Oral Clinical Medicine, The Affiliated Hospital of Qingdao University, Qingdao, China.
  • Zheng J; Department of Oral and Maxillofacial Reconstruction, The Affiliated Hospital of Qingdao University, Qingdao, China.
  • Gu H; Key Lab of Oral Clinical Medicine, The Affiliated Hospital of Qingdao University, Qingdao, China.
  • Gao L; Department of Oral and Maxillofacial Reconstruction, The Affiliated Hospital of Qingdao University, Qingdao, China.
  • Zhi K; School of Stomatology, Qingdao University, Qingdao, China.
Oral Dis ; 2024 Aug 02.
Article en En | MEDLINE | ID: mdl-39092614
ABSTRACT

OBJECTIVE:

To investigate the relationship between the expression of PD-L1 in OSCC and the clinicopathological features and prognosis of patients.

METHODS:

We retrospectively analyzed the clinicopathological data and prognosis of 381 OSCC patients. Immunohistochemical staining was performed on OSCC tumor specimens, and the expression level of PD-L1 was evaluated according to the combined positive score (CPS). Kaplan-Meier analysis was used to identify the effect of PD-L1 expression and clinicopathological features on the prognosis of patients. Univariate and multivariate Cox regression analyses were conducted to determine the hazard factors affecting the prognosis of patients.

RESULTS:

PD-L1 overexpression was significantly associated with cervical lymph node metastasis (p = 0.018), worse clinical stage (p = 0.022), worse tumor differentiation (p = 0.046), and worse depth of invasion (DOI) (p = 0.003). Poorer clinical stage and degree of tumor differentiation were significantly associated with poorer OS and DSS in patients. PD-L1 expression was not associated with prognosis in patients with OSCC.

CONCLUSIONS:

High PD-L1 expression was significantly associated with higher tumor malignancy in OSCC patients. Poorer clinical stage and degree of tumor differentiation were associated with poor prognosis in OSCC patients. Our results may help clinicians develop more appropriate individualized treatment strategies for their patients, thus improving their outcomes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Oral Dis Asunto de la revista: ODONTOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Dinamarca
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Oral Dis Asunto de la revista: ODONTOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Dinamarca