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Speech markers of depression dimensions across cognitive status.
Soleimani, Laili; Ouyang, Yuxia; Cho, Sunghye; Kia, Arash; Beeri, Michal Schnaider; Lin, Hung-Mo; Ravona-Springer, Ramit; Ramsingh, Nadia; Liberman, Mark Y; Grossman, Murray; Nevler, Naomi.
Afiliación
  • Soleimani L; Icahn School of Medicine at Mount Sinai New York New York USA.
  • Ouyang Y; Icahn School of Medicine at Mount Sinai New York New York USA.
  • Cho S; Linguistic Data Consortium University of Pennsylvania Philadelphia Pennsylvania USA.
  • Kia A; Icahn School of Medicine at Mount Sinai New York New York USA.
  • Beeri MS; Rutgers Robert Wood Johnson Medical School New Brunswick New Jersey USA.
  • Lin HM; Department of Anesthesiology Yale School of Medicine New Haven Connecticut USA.
  • Ravona-Springer R; The Joseph Sagol Neuroscience Center Sheba Medical Center Tel-Hashomer Israel.
  • Ramsingh N; Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel.
  • Liberman MY; Icahn School of Medicine at Mount Sinai New York New York USA.
  • Grossman M; Linguistic Data Consortium University of Pennsylvania Philadelphia Pennsylvania USA.
  • Nevler N; Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA.
Alzheimers Dement (Amst) ; 16(3): e12604, 2024.
Article en En | MEDLINE | ID: mdl-39092182
ABSTRACT

Introduction:

Depression and its components significantly impact dementia prediction and severity, necessitating reliable objective measures for quantification.

Methods:

We investigated associations between emotion-based speech measures (valence, arousal, and dominance) during picture descriptions and depression dimensions derived from the geriatric depression scale (GDS, dysphoria, withdrawal-apathy-vigor (WAV), anxiety, hopelessness, and subjective memory complaint).

Results:

Higher WAV was associated with more negative valence (estimate = -0.133, p = 0.030). While interactions of apolipoprotein E (APOE) 4 status with depression dimensions on emotional valence did not reach significance, there was a trend for more negative valence with higher dysphoria in those with at least one APOE4 allele (estimate = -0.404, p = 0.0846). Associations were similar irrespective of dementia severity.

Discussion:

Our study underscores the potential utility of speech biomarkers in characterizing depression dimensions. In future research, using emotionally charged stimuli may enhance emotional measure elicitation. The role of APOE on the interaction of speech markers and depression dimensions warrants further exploration with greater sample sizes. Highlights Participants reporting higher apathy used more negative words to describe a neutral picture.Those with higher dysphoria and at least one APOE4 allele also tended to use more negative words.Our results suggest the potential use of speech biomarkers in characterizing depression dimensions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Alzheimers Dement (Amst) Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Alzheimers Dement (Amst) Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos