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Investigating the Immune-Stimulating Potential of ß-Glucan from Aureobasidium pullulans in Cancer Immunotherapy.
Jeong, Jae-Hyeon; Kim, Dae-Joon; Hong, Seong-Jin; Ahn, Jae-Hee; Lee, Dong-Ju; Jang, Ah-Ra; Kim, Sungyun; Cho, Hyun-Jong; Lee, Jae-Young; Park, Jong-Hwan; Kim, Young-Min; Ko, Hyun-Jeong.
Afiliación
  • Jeong JH; Department of Pharmacy, Kangwon National University, Chuncheon 24341, Republic of Korea.
  • Kim DJ; KNU Researcher training program for Innovative Drug Development Research Team for Intractable Diseases (BK21 plus), Kangwon National University, Chuncheon 24341, Republic of Korea.
  • Hong SJ; Global/Gangwon Innovative Biologics-Regional Leading Research Center (GIB-RLRC), Kangwon National University, Chuncheon 24341, Republic of Korea.
  • Ahn JH; Department of Pharmacy, Kangwon National University, Chuncheon 24341, Republic of Korea.
  • Lee DJ; KNU Researcher training program for Innovative Drug Development Research Team for Intractable Diseases (BK21 plus), Kangwon National University, Chuncheon 24341, Republic of Korea.
  • Jang AR; Global/Gangwon Innovative Biologics-Regional Leading Research Center (GIB-RLRC), Kangwon National University, Chuncheon 24341, Republic of Korea.
  • Kim S; Institute of Agricultural Science and Technology, Chonnam National University, Gwangju 61186, Republic of Korea.
  • Cho HJ; Department of Integrative Food, Bioscience and Biotechnology, Chonnam National University, Gwangju 61186, Republic of Korea.
  • Lee JY; Department of Pharmacy, Kangwon National University, Chuncheon 24341, Republic of Korea.
  • Park JH; Global/Gangwon Innovative Biologics-Regional Leading Research Center (GIB-RLRC), Kangwon National University, Chuncheon 24341, Republic of Korea.
  • Kim YM; Department of Pharmacy, Kangwon National University, Chuncheon 24341, Republic of Korea.
  • Ko HJ; KNU Researcher training program for Innovative Drug Development Research Team for Intractable Diseases (BK21 plus), Kangwon National University, Chuncheon 24341, Republic of Korea.
Biomol Ther (Seoul) ; 32(5): 556-567, 2024 Sep 01.
Article en En | MEDLINE | ID: mdl-39091181
ABSTRACT
ß-glucan, a polysaccharide found in various sources, exhibits unique physicochemical properties, yet its high polymerization limits clinical applications because of its solubility. Addressing this limitation, we introduce PPTEE-glycan, a highly purified soluble ß-1,3/1,6-glucan derived from Aureobasidium pullulans. The refined PPTEE-glycan demonstrated robust immune stimulation in vitro, activated dendritic cells, and enhanced co-stimulatory markers, cytokines, and cross-presentation. Formulated as a PPTEE + microemulsion (ME), it elevated immune responses in vivo, promoting antigen-specific antibodies and CD8+ T cell proliferation. Intratumoral administration of PPTEE + ME in tumor-bearing mice induced notable tumor regression, which was linked to the activation of immunosuppressive cells. This study highlights the potential of high-purity Aureobasidium pullulans-derived ß-glucan, particularly PPTEE, as promising immune adjuvants, offering novel avenues for advancing cancer immunotherapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biomol Ther (Seoul) Año: 2024 Tipo del documento: Article Pais de publicación:
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biomol Ther (Seoul) Año: 2024 Tipo del documento: Article Pais de publicación: