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The Association of Obstructive Sleep Apnea with Urological Cancer Incidence and Mortality-A Systematic Review and Meta-analysis.
Yeo, Brian Sheng Yep; Yap, Dominic Wei Ting; Tan, Nicole Kye Wen; Tan, Benjamin Kye Jyn; Teo, Yao Hao; Teo, Yao Neng; Lee, Alvin; See, Anna; Ho, Henry Sun Sien; Teoh, Jeremy Yuen-Chun; Chen, Kenneth; Toh, Song Tar.
Afiliación
  • Yeo BSY; Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore.
  • Yap DWT; Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore.
  • Tan NKW; Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore.
  • Tan BKJ; Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore; Department of Otorhinolaryngology-Head & Neck Surgery, Singapore General Hospital, Singapore; Surgery Academic Clinical Program, Duke-NUS Medical School, Singapore.
  • Teo YH; Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore.
  • Teo YN; Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore.
  • Lee A; Department of Urology, Singapore General Hospital, Singapore; Division of Surgery and Surgical Oncology, National Cancer Centre Singapore, Singapore.
  • See A; Division of Surgery and Surgical Oncology, National Cancer Centre Singapore, Singapore; Department of Otorhinolaryngology-Head & Neck Surgery, Singapore General Hospital, Singapore; Surgery Academic Clinical Program, Duke-NUS Medical School, Singapore.
  • Ho HSS; Department of Urology, Singapore General Hospital, Singapore; Division of Surgery and Surgical Oncology, National Cancer Centre Singapore, Singapore; Surgery Academic Clinical Program, Duke-NUS Medical School, Singapore.
  • Teoh JY; SH Ho Urology Centre, Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China.
  • Chen K; Department of Urology, Singapore General Hospital, Singapore; Division of Surgery and Surgical Oncology, National Cancer Centre Singapore, Singapore; Surgery Academic Clinical Program, Duke-NUS Medical School, Singapore. Electronic address: kenneth.chen@singhealth.com.sg.
  • Toh ST; Division of Surgery and Surgical Oncology, National Cancer Centre Singapore, Singapore; Department of Otorhinolaryngology-Head & Neck Surgery, Singapore General Hospital, Singapore; Surgery Academic Clinical Program, Duke-NUS Medical School, Singapore; SingHealth Duke-NUS Sleep Centre, Singapore
Eur Urol Focus ; 2024 Jul 31.
Article en En | MEDLINE | ID: mdl-39089967
ABSTRACT
BACKGROUND AND

OBJECTIVE:

While obstructive sleep apnea (OSA) and urological cancer are both strongly associated with hypoxia, controversy exists regarding their association with each other. This study aims to summarize and synthesize evidence to clarify the association between OSA and urological cancer incidence and mortality.

METHODS:

According to a prespecified protocol, PubMed, Embase, Cochrane Library, and Scopus were searched from inception to November 16, 2023, for observational and randomized studies reporting the association of OSA with urological cancer incidence or mortality. We pooled maximally covariate-adjusted hazard ratios (HRs) using a random-effects inverse variance-weighted model. Two reviewers independently assessed the quality of evidence using the Newcastle-Ottawa Scale and the Grading of Recommendations, Assessment, Development and Evaluation framework. KEY FINDINGS AND

LIMITATIONS:

From 1814 records, we included 12 studies comprising 9 290 818 participants in total, of which nine studies were analyzed quantitatively. OSA patients had an increased risk of kidney (HR 1.75, 95% confidence interval [CI] 1.21-2.53) and bladder (HR 1.76, 95% CI 1.05-2.96) cancer. However, OSA was not associated with prostate cancer incidence (HR 1.29, 95% CI 0.82-2.04). We systematically reviewed evidence surrounding OSA and testicular cancer incidence and urological cancer mortality. CONCLUSIONS AND CLINICAL IMPLICATIONS OSA may be associated with a higher risk of kidney and bladder cancer, but not prostate cancer. Future work may help clarify the possibility of a dose-response relationship between OSA and urological cancer, and the effect of OSA treatment on urological cancer incidence or progression. PATIENT

SUMMARY:

This research highlights a potential longitudinal association between OSA and kidney and bladder cancer, but not prostate cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Eur Urol Focus Año: 2024 Tipo del documento: Article País de afiliación: Singapur Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Eur Urol Focus Año: 2024 Tipo del documento: Article País de afiliación: Singapur Pais de publicación: Países Bajos