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An arabinoxylan (AOP70-1) isolated from Alpinia oxyphylla alleviates neuroinflammation and neurotoxicity by TLR4/MyD88/NF-κB pathway.
Chang, Xiao; Zhang, Dawei; Shi, Wenting; Yu, Qian; Wu, Zhijian; Yang, Junqiang; Tang, Zonggui; Chen, Haiyun; Yan, Chunyan.
Afiliación
  • Chang X; School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.
  • Zhang D; School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China. Electronic address: dwzhang@gdpu.edu.cn.
  • Shi W; School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.
  • Yu Q; School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.
  • Wu Z; School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.
  • Yang J; School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.
  • Tang Z; School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.
  • Chen H; School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.
  • Yan C; School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China. Electronic address: ycybridge@gdpu.edu.cn.
Int J Biol Macromol ; 277(Pt 3): 134339, 2024 Oct.
Article en En | MEDLINE | ID: mdl-39089558
ABSTRACT
Alpinia oxyphylla is famous for its neuroprotective and memory-improving effects. A crude polysaccharide AO70 from A. oxyphylla remarkably ameliorated neuroinflammation and cognitive dysfunction in Alzheimer's disease mice. This study aimed to explore the bioactive component of AO70 and its mechanism of action. A homogeneous polysaccharide (AOP70-1) rich in arabinose and xylose was purified from AO70, which was consisted of α-L-Araf-(1→, →5)-α-L-Araf-(1→, ß-D-Xylp-(1→,→2,4)-ß-D-Xylp-(1→, →2,3,4)-ß-D-Xylp-(1→, α-L-Rhap-(1→, α-D-Manp-(1→, →4)-α-D-Glcp-(1→, →4)-α-D-GlcpA-(1→, ß-D-Galp-(1→, →2)-α-D-Galp-(1→, →6)-α-D-Galp-(1 â†’ and →3,6)-α-D-Manp-(1 →. AOP70-1 (2.5, 5, 10 µM) significantly suppressed NO, IL-1ß, and TNF-α production in a concentration-dependent manner and inhibited the migration of BV2 microglia. AOP70-1 inhibited LPS-mediated activation of Toll-like receptor 4 (TLR4), myeloid differentiation primary response protein (MyD88), and nuclear factor kappa B (NF-κB). Moreover, AOP70-1 exerted neuroprotection on SH-SY5Y cells and primary neurons by reducing neuronal apoptosis (72 %, 44 %), alleviating ROS accumulation (63 %, 55 %), and improving mitochondrial membrane potential (63 %, 77 %). Overall, AOP70-1 is one of the major bioactive components in AO70 from A. oxyphylla, which has great potential in the prevention and treatment of neuroinflammation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Xilanos / Transducción de Señal / Alpinia / Enfermedades Neuroinflamatorias Límite: Animals / Humans Idioma: En Revista: Int J Biol Macromol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Xilanos / Transducción de Señal / Alpinia / Enfermedades Neuroinflamatorias Límite: Animals / Humans Idioma: En Revista: Int J Biol Macromol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos