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Exploring bradykinin: A common mediator in the pathophysiology of sepsis and atherosclerotic cardiovascular disease.
Siti-Zubaidah, Mohd Zahari; Harafinova, Harman-Shah; Liba, Abdullahi Nuradeen; Nordin, Muhammad Luqman; Hambali, Kamarul Ariffin; Siti, Hawa Nordin.
Afiliación
  • Siti-Zubaidah MZ; Department of Anaesthesia and Intensive Care, National Heart Institute, Jalan Tun Razak, 50400 Kuala Lumpur, Malaysia. Electronic address: dr.sitizubaidah@ijn.com.my.
  • Harafinova HS; Department of Internal Medicine, Faculty of Medicine, Universiti Sultan Zainal Abidin, Jalan Sultan Mahmud, 20400 Kuala Terengganu, Terengganu, Malaysia. Electronic address: harafinovahshah@unisza.edu.my.
  • Liba AN; Department of Veterinary Clinical Studies, Faculty of Veterinary Medicine, Universiti Malaysia Kelantan, Pengkalan Chepa, Kota Bharu, 16100, Kelantan, Malaysia.
  • Nordin ML; Department of Veterinary Clinical Studies, Faculty of Veterinary Medicine, Universiti Malaysia Kelantan, Pengkalan Chepa, Kota Bharu, 16100, Kelantan, Malaysia; Department of Pharmaceutical Technology, Faculty of Pharmacy, Universiti Malaya, 50603 Kuala Lumpur, Malaysia. Electronic address: luqman.n
  • Hambali KA; Faculty of Earth Science, Universiti Malaysia Kelantan, Jeli, 17600, Kelantan, Malaysia; Animal and Wildlife Research Group, Faculty of Earth Science, Jeli Campus, Universiti Malaysia Kelantan, 17600, Kelantan, Malaysia. Electronic address: kamarul@umk.edu.my.
  • Siti HN; Department of Pharmacology, Faculty of Medicine, Universiti Sultan Zainal Abidin, Jalan Sultan Mahmud, 20400 Kuala Terengganu, Terengganu, Malaysia. Electronic address: hawanordin@unisza.edu.my.
Vascul Pharmacol ; 156: 107414, 2024 Sep.
Article en En | MEDLINE | ID: mdl-39089528
ABSTRACT
Sepsis and atherosclerotic cardiovascular disease (ASCVD) are major health challenges involving complex processes like inflammation, renin-angiotensin system (RAS) dysregulation, and thrombosis. Despite distinct clinical symptoms, both conditions share mechanisms mediated by bradykinin. This review explores bradykinin's role in inflammation, RAS modulation, and thrombosis in sepsis and ASCVD. In sepsis, variable kininogen-bradykinin levels may correlate with disease severity and progression, though the effect of bradykinin receptor modulation on inflammation remains uncertain. RAS activation is present in both diseases, with sepsis showing variable or low levels of Ang II, ACE, and ACE2, while ASCVD consistently exhibits elevated levels. Bradykinin may act as a mediator for ACE2 and AT2 receptor effects in RAS regulation. It may influence clotting and fibrinolysis in sepsis-associated coagulopathy, but evidence for an antithrombotic effect in ASCVD is insufficient. Understanding bradykinin's role in these shared pathologies could guide therapeutic and monitoring strategies and inform future research.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistema Renina-Angiotensina / Coagulación Sanguínea / Bradiquinina / Transducción de Señal / Sepsis / Aterosclerosis Límite: Animals / Humans Idioma: En Revista: Vascul Pharmacol Asunto de la revista: ANGIOLOGIA / FARMACOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistema Renina-Angiotensina / Coagulación Sanguínea / Bradiquinina / Transducción de Señal / Sepsis / Aterosclerosis Límite: Animals / Humans Idioma: En Revista: Vascul Pharmacol Asunto de la revista: ANGIOLOGIA / FARMACOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos