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Nanocellulose-alginate composite beads for improving Ciprofloxacin bioavailability.
Luong, Huynh Vu Thanh; Nguyen, Ngoc Yen; Diep, My Tran; Pham, Duy Toan; Cao, Luu Ngoc Hanh; Nguyen, Trong Tuan.
Afiliación
  • Luong HVT; Faculty of Chemical Engineering, Can Tho University, 3/2 street, Ninh Kieu district, Can Tho 94000, Viet Nam; Applied Chemical Engineering Laboratory, Can Tho University, 3/2 street, Ninh Kieu district, Can Tho 94000, Viet Nam. Electronic address: lhvthanh@ctu.edu.vn.
  • Nguyen NY; Applied Chemical Engineering Laboratory, Can Tho University, 3/2 street, Ninh Kieu district, Can Tho 94000, Viet Nam; Department of Health Sciences, College of Natural Sciences, Can Tho University, 3/2 street, Ninh Kieu district, Can Tho 94000, Viet Nam.
  • Diep MT; Faculty of Chemical Engineering, Can Tho University, 3/2 street, Ninh Kieu district, Can Tho 94000, Viet Nam; Applied Chemical Engineering Laboratory, Can Tho University, 3/2 street, Ninh Kieu district, Can Tho 94000, Viet Nam.
  • Pham DT; Department of Health Sciences, College of Natural Sciences, Can Tho University, 3/2 street, Ninh Kieu district, Can Tho 94000, Viet Nam.
  • Cao LNH; Faculty of Chemical Engineering, Can Tho University, 3/2 street, Ninh Kieu district, Can Tho 94000, Viet Nam.
  • Nguyen TT; Department of Health Sciences, College of Natural Sciences, Can Tho University, 3/2 street, Ninh Kieu district, Can Tho 94000, Viet Nam.
Int J Biol Macromol ; 277(Pt 2): 134136, 2024 Oct.
Article en En | MEDLINE | ID: mdl-39088940
ABSTRACT
Nanocellulose is a potential material utilized in numerous biomedical applications. However, its hydrophilic characteristic and uncontrolled encapsulated drug release hinders nanocellulose uses in oral drug administration. Thus, this work developed novel nanocellulose/alginate composite (CNC/Alg) beads for oral delivery and bioavailability enhancement of a model drug, Ciprofloxacin (CIP). CNC was green synthesized employing electrolysis process from sugarcane bagasse. CNC/Alg beads were formulated by dropwise adding CNC-Alg mixture in CaCl2 solution at room temperature. CIP was incorporated into CNC/Alg beads by adsorption technique. X-ray diffractometry and Fourier-transform infrared spectra images showed that the beads were effectively produced with high crystallinity of 75.5 %, and the typical bond of cellulose and alginate. Within 4 h of adsorption, CIP loading efficiency reached 45.27 %, with 87.2 % molecules in the zwitterionic state. The adsorption followed Elovich and pseudo-second-order models, indicating a multi-mechanism including both physical and chemical adsorptions. Importantly, in gastrointestinal tract, the beads could protect CIP from acidic stomach environment while releasing it sustainably in simulated intestinal condition (75.05 %). The beads also showed strong antibacterial activity against both Gram(-) and Gram(+) bacteria, as evidenced by low IC50 and minimum inhibitory concentration values. Finally, CNC/Alg beads could improve CIP bioavailability for effective oral drug delivery route.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Disponibilidad Biológica / Ciprofloxacina / Celulosa / Alginatos / Antibacterianos Idioma: En Revista: Int J Biol Macromol Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Disponibilidad Biológica / Ciprofloxacina / Celulosa / Alginatos / Antibacterianos Idioma: En Revista: Int J Biol Macromol Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos