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Prenatal protein malnutrition decreases neuron numbers in the parahippocampal region but not prefrontal cortex in adult rats.
Amaral, A C; Lister, J P; Rueckemann, J W; Wojnarowicz, M W; McGaughy, J A; Mokler, D J; Galler, J R; Rosene, D L; Rushmore, R J.
Afiliación
  • Amaral AC; Department of Anatomy & Neurobiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
  • Lister JP; Department of Anatomy & Neurobiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
  • Rueckemann JW; Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, CA, USA.
  • Wojnarowicz MW; Department of Physiology and Biophysics, University of Washington, Seattle, WA, USA.
  • McGaughy JA; Department of Pathology & Laboratory Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
  • Mokler DJ; Department of Psychology, University of New Hampshire, Durham, NH, USA.
  • Galler JR; Department of Biomedical Sciences, University of New England, Biddeford, ME, USA.
  • Rosene DL; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
  • Rushmore RJ; Department of Pediatrics & Division of Gastroenterology and Nutrition, MassGeneral Hospital for Children, Boston, MA, USA.
Nutr Neurosci ; : 1-14, 2024 Aug 01.
Article en En | MEDLINE | ID: mdl-39088448
ABSTRACT

OBJECTIVE:

Prenatal protein malnutrition produces anatomical and functional changes in the developing brain that persist despite immediate postnatal nutritional rehabilitation. Brain networks of prenatally malnourished animals show diminished activation of prefrontal areas and an increased activation of hippocampal regions during an attentional task [1]. While a reduction in cell number has been documented in hippocampal subfield CA1, nothing is known about changes in neuron numbers in the prefrontal or parahippocampal cortices.

METHODS:

In the present study, we used unbiased stereology to investigate the effect of prenatal protein malnutrition on the neuron numbers in the medial prefrontal cortex and the cortices of the parahippocampal region that comprise the larger functional network.

RESULTS:

Results show that prenatal protein malnutrition does not cause changes in the neuronal population in the medial prefrontal cortex of adult rats, indicating that the decrease in functional activation during attentional tasks is not due to a reduction in the number of neurons. Results also show that prenatal protein malnutrition is associated with a reduction in neuron numbers in specific parahippocampal subregions the medial entorhinal cortex and presubiculum.

DISCUSSION:

The affected regions along with CA1 comprise a tightly interconnected circuit, suggesting that prenatal malnutrition confers a vulnerability to specific hippocampal circuits. These findings are consistent with the idea that prenatal protein malnutrition produces a reorganization of structural and functional networks, which may underlie observed alterations in attentional processes and capabilities.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Nutr Neurosci Asunto de la revista: CIENCIAS DA NUTRICAO / NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Nutr Neurosci Asunto de la revista: CIENCIAS DA NUTRICAO / NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido