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Human milk antibodies to global pathogens reveal geographic and interindividual variations in IgA and IgG.
Campo, Joseph J; Seppo, Antti E; Randall, Arlo Z; Pablo, Jozelyn; Hung, Chris; Teng, Andy; Shandling, Adam D; Truong, Johnathon; Oberai, Amit; Miller, James; Iqbal, Najeeha Talat; Peñataro Yori, Pablo; Kukkonen, Anna Kaarina; Kuitunen, Mikael; Guterman, L Beryl; Morris, Shaun K; Pell, Lisa G; Al Mahmud, Abdullah; Ramakrishan, Girija; Heinz, Eva; Kirkpatrick, Beth D; Faruque, Abu Sg; Haque, Rashidul; Looney, R John; Kosek, Margaret N; Savilahti, Erkki; Omer, Saad B; Roth, Daniel E; Petri, William A; Järvinen, Kirsi M.
Afiliación
  • Campo JJ; Antigen Discovery Incorporated, Irvine, California, USA.
  • Seppo AE; Department of Pediatrics, Division of Allergy and Immunology, University of Rochester School of Medicine, Rochester, New York, USA.
  • Randall AZ; Antigen Discovery Incorporated, Irvine, California, USA.
  • Pablo J; Antigen Discovery Incorporated, Irvine, California, USA.
  • Hung C; Antigen Discovery Incorporated, Irvine, California, USA.
  • Teng A; Antigen Discovery Incorporated, Irvine, California, USA.
  • Shandling AD; Antigen Discovery Incorporated, Irvine, California, USA.
  • Truong J; Antigen Discovery Incorporated, Irvine, California, USA.
  • Oberai A; Antigen Discovery Incorporated, Irvine, California, USA.
  • Miller J; Department of Pediatrics, Division of Allergy and Immunology, University of Rochester School of Medicine, Rochester, New York, USA.
  • Iqbal NT; Department of Paediatrics and Child Health, Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan.
  • Peñataro Yori P; Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia, USA.
  • Kukkonen AK; New Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Kuitunen M; New Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Guterman LB; Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
  • Morris SK; Centre for Global Child Health, Hospital for Sick Children, Toronto, Ontario, Canada.
  • Pell LG; Department of Pediatrics, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada.
  • Al Mahmud A; Centre for Global Child Health, Hospital for Sick Children, Toronto, Ontario, Canada.
  • Ramakrishan G; Nutrition and Clinical Services Division, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
  • Heinz E; Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia, USA.
  • Kirkpatrick BD; Departments of Vector Biology and Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK.
  • Faruque AS; Wellcome Sanger Institute, Parasites and Microbes, Cambridge, UK.
  • Haque R; Vaccine Testing Center and Department of Microbiology and Molecular Genetics, The University of Vermont College of Medicine, Burlington, Vermont, USA.
  • Looney RJ; Emerging Infection and Parasitology Laboratory, Division of Infectious Diseases, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
  • Kosek MN; Emerging Infection and Parasitology Laboratory, Division of Infectious Diseases, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
  • Savilahti E; Department of Medicine, Division of Allergy, Immunology and Rheumatology, University of Rochester School of Medicine, Rochester, New York, USA.
  • Omer SB; Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia, USA.
  • Roth DE; New Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Petri WA; Peter O'Donnell Jr. School of Public Health, Dallas, Texas, USA.
  • Järvinen KM; Centre for Global Child Health, Hospital for Sick Children, Toronto, Ontario, Canada.
J Clin Invest ; 134(15)2024 Jun 11.
Article en En | MEDLINE | ID: mdl-39087469
ABSTRACT
BACKGROUNDThe use of high-throughput technologies has enabled rapid advancement in the knowledge of host immune responses to pathogens. Our objective was to compare the repertoire, protection, and maternal factors associated with human milk antibodies to infectious pathogens in different economic and geographic locations.METHODSUsing multipathogen protein microarrays, 878 milk and 94 paired serum samples collected from 695 women in 5 high and low-to-middle income countries (Bangladesh, Finland, Peru, Pakistan, and the United States) were assessed for specific IgA and IgG antibodies to 1,607 proteins from 30 enteric, respiratory, and bloodborne pathogens.RESULTSThe antibody coverage across enteric and respiratory pathogens was highest in Bangladeshi and Pakistani cohorts and lowest in the U.S. and Finland. While some pathogens induced a dominant IgA response (Campylobacter, Klebsiella, Acinetobacter, Cryptosporidium, and pertussis), others elicited both IgA and IgG antibodies in milk and serum, possibly related to the invasiveness of the infection (Shigella, enteropathogenic E. coli "EPEC", Streptococcus pneumoniae, Staphylococcus aureus, and Group B Streptococcus). Besides the differences between economic regions and decreases in concentrations over time, human milk IgA and IgG antibody concentrations were lower in mothers with high BMI and higher parity, respectively. In Bangladeshi infants, a higher specific IgA concentration in human milk was associated with delayed time to rotavirus infection, implying protective properties of antirotavirus antibodies, whereas a higher IgA antibody concentration was associated with greater incidence of Campylobacter infection.CONCLUSIONThis comprehensive assessment of human milk antibody profiles may be used to guide the development of passive protection strategies against infant morbidity and mortality.FUNDINGBill and Melinda Gates Foundation grant OPP1172222 (to KMJ); Bill and Melinda Gates Foundation grant OPP1066764 funded the MDIG trial (to DER); University of Rochester CTSI and Environmental Health Sciences Center funded the Rochester Lifestyle study (to RJL); and R01 AI043596 funded PROVIDE (to WAP).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inmunoglobulina A / Inmunoglobulina G / Leche Humana Límite: Adult / Female / Humans País/Región como asunto: Asia Idioma: En Revista: J Clin Invest Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inmunoglobulina A / Inmunoglobulina G / Leche Humana Límite: Adult / Female / Humans País/Región como asunto: Asia Idioma: En Revista: J Clin Invest Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos