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Impact of TP53 mutations on brain metastasis control in non-small cell lung cancer patients undergoing stereotactic radiosurgery.
Leng, Jim X; Su, Chang; Carpenter, David J; Floyd, Warren; Vaios, Eugene; Shenker, Rachel; Hendrickson, Peter G; Giles, Will; Mullikin, Trey; Floyd, Scott R; Kirkpatrick, John P; Green, Michelle; Reitman, Zachary J.
Afiliación
  • Leng JX; Department of Radiation Oncology, Duke University Medical Center, Durham, NC, 27710, USA.
  • Su C; Department of Radiation Oncology, Duke University Medical Center, Durham, NC, 27710, USA.
  • Carpenter DJ; Department of Radiation Oncology, Duke University Medical Center, Durham, NC, 27710, USA.
  • Floyd W; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Vaios E; Department of Radiation Oncology, Duke University Medical Center, Durham, NC, 27710, USA.
  • Shenker R; Department of Radiation Oncology, Duke University Medical Center, Durham, NC, 27710, USA.
  • Hendrickson PG; Department of Radiation Oncology, Duke University Medical Center, Durham, NC, 27710, USA.
  • Giles W; Department of Radiation Oncology, Duke University Medical Center, Durham, NC, 27710, USA.
  • Mullikin T; Department of Radiation Oncology, Duke University Medical Center, Durham, NC, 27710, USA.
  • Floyd SR; Department of Radiation Oncology, Duke University Medical Center, Durham, NC, 27710, USA.
  • Kirkpatrick JP; Department of Radiation Oncology, Duke University Medical Center, Durham, NC, 27710, USA.
  • Green M; Department of Pathology, Duke University Medical Center, Durham, NC, 27710, USA.
  • Reitman ZJ; Department of Radiation Oncology, Duke University Medical Center, Durham, NC, 27710, USA.
J Radiosurg SBRT ; 9(2): 91-99, 2024.
Article en En | MEDLINE | ID: mdl-39087065
ABSTRACT

Purpose:

To investigate whether TP53 variants may be correlated with overall survival and local control following stereotactic radiosurgery (SRS) for brain metastases (BMs) from non-small cell lung cancer (NSCLC).

Methods:

Patients undergoing an initial course of SRS for NSCLC brain metastases between 1/2015 and 12/2020 were retrospectively identified. Overall survival and freedom from local intracranial progression (FFLIP) were estimated via Kaplan-Meier method. Cox models assessed TP53 variant status (pathogenic variant, PV; variant not detected, ND).

Results:

255 patients underwent molecular profiling for TP53, among whom 144 (56%) had a TP53 PV. Median follow-up was 11.6 months. OS was not significantly different across TP53 status. A trend toward superior FFLIP was observed for PV (95% CI 62.9 months-NR) versus ND patients (95% CI 29.4 months-NR; p=0.06). Superior FFLIP was observed for patients with one TP53 variant versus those with TP53 ND.

Conclusion:

Among NSCLC patients with BMs, the potential association between TP53 status and post-SRS FFLIP warrants further investigation in a larger prospective cohort.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Radiosurg SBRT Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Radiosurg SBRT Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos