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Serum IL-6 as a Surrogate Biomarker of Post-operative Complications in Invasive Orthopaedic Surgeries: A Prospective Observational Study.
Laishram, Kanchana; Borgohain, Bhaskar; Laishram, Aparna; Khonglah, Tashi G; Ruram, Alice A; Debbarma, Sachlang.
Afiliación
  • Laishram K; Department of Orthopaedics and Trauma, NEIGRIHMS, Shillong, Meghalaya 793018 India.
  • Borgohain B; Department of Orthopaedics and Trauma, NEIGRIHMS, Shillong, Meghalaya 793018 India.
  • Laishram A; Department of Biochemistry, NEIGRIHMS, Shillong, Meghalaya 793018 India.
  • Khonglah TG; Department of Orthopaedics and Trauma, NEIGRIHMS, Shillong, Meghalaya 793018 India.
  • Ruram AA; Department of Biochemistry, NEIGRIHMS, Shillong, Meghalaya 793018 India.
  • Debbarma S; Department of Orthopaedics and Trauma, NEIGRIHMS, Shillong, Meghalaya 793018 India.
Indian J Orthop ; 58(8): 1153-1158, 2024 Aug.
Article en En | MEDLINE | ID: mdl-39087046
ABSTRACT

Background:

Interleukin-6 (IL-6) is a cytokine released in response to tissue injury. Elevated serum IL-6 levels in trauma patients have been linked with increased risk of complications such as inapparent hypoxia (SpO2 < 94%), acute respiratory distress syndrome, fat embolism syndrome (FES), systemic inflammatory response syndrome, multiple organ dysfunction syndrome and sepsis. This study aims to determine the role of serum IL-6 as surrogate biomarker of post-operative complications after invasive orthopaedic surgeries.

Methods:

Thirty-seven adults between 18 and 65 years of age undergoing invasive orthopaedic surgeries were included in this hospital-based study. Serum IL-6 levels were estimated serially in the pre-operative period, after 24 h and 7 days post-operatively. Cases were monitored for post-operative complications.

Results:

Serum IL-6 levels showed maximum rise in the first 24 h post-operatively especially among older patients (> 60 years). Older patients undergoing bipolar hemiarthroplasty for neck of femur fracture showed highest median post-operative IL-6 level of 258 pg/ml. Serum IL-6 level > 130 pg/ml measured 24 h after surgery was predictive of post-operative complications (sensitivity of 75%). Among the cases with post-operative complications, inapparent hypoxia was the most common complication/event observed. Cases with sub-clinical FES had highest level of serum IL-6 in first 24 h following surgery with median IL-6 level of 300 pg/ml (range 155-444 pg/ml).

Conclusion:

Monitoring serum IL-6 level may help in both anticipation and early detection of post-operative complications in patients undergoing invasive orthopaedic surgeries; potentially enhancing patient safety.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Indian J Orthop Año: 2024 Tipo del documento: Article Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Indian J Orthop Año: 2024 Tipo del documento: Article Pais de publicación: Suiza