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Predictive factors for COVID-19 severity and mortality in hospitalized children.
Mahmoudi, Shima; Pourakbari, Babak; Jafari, Erfaneh; Eshaghi, Hamid; Movahedi, Zahra; Heydari, Hosein; Mohammadian, Maryam; Rahmati, Mohammad Bagher; Tariverdi, Marjan; Shalchi, Zohreh; Navaeian, Amene; Mamishi, Setareh.
Afiliación
  • Mahmoudi S; Biotechnology Centre, Silesian University of Technology, Gliwice, 44-100, Poland.
  • Pourakbari B; Pediatric Infectious Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran.
  • Jafari E; Pediatric Infectious Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran. pourakbari@tums.ac.ir.
  • Eshaghi H; Pediatric Infectious Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran.
  • Movahedi Z; Department of Infectious Diseases, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
  • Heydari H; Pediatric Medicine Research Center, Qom University of Medical Sciences, Qom, Iran.
  • Mohammadian M; Pediatric Medicine Research Center, Qom University of Medical Sciences, Qom, Iran.
  • Rahmati MB; Department of Pediatric, Clinical Research Development Center of Children Hospital, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
  • Tariverdi M; Department of Pediatric, Clinical Research Development Center of Children Hospital, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
  • Shalchi Z; Department of Pediatric, Clinical Research Development Center of Children Hospital, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
  • Navaeian A; Department of Pediatric, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
  • Mamishi S; Department of Infectious Diseases, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
BMC Infect Dis ; 24(1): 757, 2024 Jul 31.
Article en En | MEDLINE | ID: mdl-39085793
ABSTRACT

BACKGROUND:

Understanding the factors influencing disease progression and severity in pediatric COVID-19 cases is essential for effective management and intervention strategies. This study aimed to evaluate the discriminative ability of clinical and laboratory parameters to identify predictors of COVID-19 severity and mortality in hospitalized children.

METHODS:

In this multicenter retrospective cohort study, we included 468 pediatric patients with COVID-19. We developed a predictive model using their demographic, clinical, and laboratory data. The performance of the model was assessed using various metrics including sensitivity, specificity, positive predictive value rates, and receiver operating characteristics (ROC).

RESULTS:

Our findings demonstrated strong discriminatory power, with an area under the curve (AUC) of 0.818 for severity and 0.873 for mortality prediction. Key risk factors for severe COVID-19 in children include low albumin levels, elevated C-reactive protein (CRP), lactate dehydrogenase (LDH), and underlying medical conditions. Furthermore, ROC curve analysis highlights the predictive value of CRP, LDH, and albumin, with AUC values of 0.789, 0.752, and 0.758, respectively.

CONCLUSION:

Our study indicates that laboratory values are valuable in predicting COVID-19 severity in children. Various factors, including CRP, LDH, and albumin levels, demonstrated statistically significant differences between patient groups, suggesting their potential as predictive markers for disease severity. Implementing predictive analyses based on these markers could aid clinicians in making informed decisions regarding patient management.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Índice de Severidad de la Enfermedad / Proteína C-Reactiva / SARS-CoV-2 / COVID-19 Límite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: BMC Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2024 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Índice de Severidad de la Enfermedad / Proteína C-Reactiva / SARS-CoV-2 / COVID-19 Límite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: BMC Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2024 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Reino Unido