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Effect of whey protein-derived decapeptide on mood status and blood variables in healthy adults: a randomized, double-blind, placebo-controlled cross-over trial.
Suzuki, Katsuya; Okamatsu, Yoriko; Uchida, Ryo; Sasahara, Ikuko; Takeshita, Masamichi; Sato, Wataru; Kitahara, Yoshiro; Murakami, Hitoshi.
Afiliación
  • Suzuki K; Institute of Food Sciences and Technologies, Ajinomoto Co., Inc, Kanagawa, 210-8681, Japan. katsuya.suzuki.4w9@asv.ajinomoto.com.
  • Okamatsu Y; Institute of Food Sciences and Technologies, Ajinomoto Co., Inc, Kanagawa, 210-8681, Japan.
  • Uchida R; Institute of Food Sciences and Technologies, Ajinomoto Co., Inc, Kanagawa, 210-8681, Japan.
  • Sasahara I; Institute of Food Sciences and Technologies, Ajinomoto Co., Inc, Kanagawa, 210-8681, Japan.
  • Takeshita M; Research Institute for Bioscience Products and Fine Chemicals, Ajinomoto Co., Inc, Kanagawa, 210-8681, Japan.
  • Sato W; Research Institute for Bioscience Products and Fine Chemicals, Ajinomoto Co., Inc, Kanagawa, 210-8681, Japan.
  • Kitahara Y; Institute of Food Sciences and Technologies, Ajinomoto Co., Inc, Kanagawa, 210-8681, Japan.
  • Murakami H; Institute of Food Sciences and Technologies, Ajinomoto Co., Inc, Kanagawa, 210-8681, Japan.
Eur J Nutr ; 2024 Jul 31.
Article en En | MEDLINE | ID: mdl-39085724
ABSTRACT

PURPOSE:

The importance of maintaining good mental health with overall well-being has recently drawn attention from various fields. Functional peptides found from various protein sources reportedly reduce mental health problems. We found a new decapeptide (AJI-801) from whey proteins, which can possibly improve mood status and increase blood acetyl-L-carnitine (ALC) and fibroblast growth factor 21 (FGF21) levels. In this study, we assessed the effects of a single intake of whey protein hydrolysate containing a high amount of AJI-801 (WPH) on blood variables and mood status.

METHODS:

A randomized, double-blind, placebo-controlled cross-over trial of two doses of WPH (100 and 500 mg) was conducted. Participants, aged between 20 and 59 years with fatigue were allocated to two groups based on the WPH doses received, and set first test food in each study. The blood ALC and FGF21 levels at baseline and after 60, 120, and 180 min of test food intake were analyzed and the responses to the questionnaire items for mood status were obtained at baseline and after 60 and 180 min of test food intake.

RESULTS:

There were no significant differences in the blood ALC and FGF21 levels between the two groups. As mood status, intake of 500-mg WPH (including 2.5-mg AJI-801) showed significant improvement in Depression/Dejection of the Profile of Mood States Questionnaire second edition and visual analog scale score for depression, as compared to the placebo.

CONCLUSIONS:

Intake of AJI-801 500-mg WPH (including 2.5-mg AJI-801) contributes to the improvement of feeling down in healthy persons with fatigue. TRIAL REGISTRATION University Hospital Medical Information Network Clinical Trial Registry (UMIN 000046829).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Eur J Nutr Asunto de la revista: CIENCIAS DA NUTRICAO Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Eur J Nutr Asunto de la revista: CIENCIAS DA NUTRICAO Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Alemania