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Alleviated diabetic osteoporosis and peripheral neuropathic pain by Rehmannia glutinosa Libosch polysaccharide via increasing regulatory T cells.
Yue, Wenjie; Sun, Na; Zhang, Jing; Zhang, Wanhao; Wu, Yueshu; Qu, Xiaochen; Zong, Junwei; Xu, Gang.
Afiliación
  • Yue W; Department of Orthopaedics, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, China.
  • Sun N; Department of Pharmacy, The Third People's Hospital of Dalian, Dalian 116091, China.
  • Zhang J; Department of Orthopaedics, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, China.
  • Zhang W; Department of Orthopaedics, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, China.
  • Wu Y; Department of Orthopaedics, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, China.
  • Qu X; Department of Orthopaedics, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, China; Key Laboratory of Molecular Mechanism for Repair and Remodeling of Orthopaedic Diseases, Dalian 116011, Liaoning Province, China.
  • Zong J; Department of Orthopaedics, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, China; Key Laboratory of Molecular Mechanism for Repair and Remodeling of Orthopaedic Diseases, Dalian 116011, Liaoning Province, China.
  • Xu G; Department of Orthopaedics, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, China; Key Laboratory of Molecular Mechanism for Repair and Remodeling of Orthopaedic Diseases, Dalian 116011, Liaoning Province, China. Electronic address: xugang@dmu.edu.cn.
Int J Biol Macromol ; 277(Pt 4): 134241, 2024 Oct.
Article en En | MEDLINE | ID: mdl-39084449
ABSTRACT
Diabetic peripheral neuropathy (DPN) and diabetic osteoporosis (DOP) are conditions that significantly impact the quality of life of patients worldwide. Rehmanniae Radix Preparata, a component of traditional Chinese medicine with a history spanning thousands of years, has been utilized in the treatment of osteoporosis and diabetes. Specifically, Rehmannia glutinosa Libosch polysaccharide (RGP), a key bioactive compound of Rehmanniae Radix Preparata, has demonstrated immune-modulating properties and beneficial effects on hyperglycemia, hyperlipidemia, and vascular inflammation in diabetic mice. Despite these known actions, the precise mechanisms of RGP in addressing DOP and DPN remain unclear. Our study aimed to explore the impact of RGP on osteoporosis and peripheral neuropathic pain in diabetic mice induced by streptozotocin (STZ). The findings revealed that RGP not only improved hyperglycemia and osteoporosis in STZ-induced diabetic mice but also enhanced osteogenesis, insulin production, and nerve health. Specifically, RGP alleviated distal pain, improved nerve conduction velocity, nerve fiber integrity, and immune cell balance in the spleen. Mechanistically, RGP was found to upregulate HDAC6 mRNA expression in regulatory T cells, potentially shedding light on novel pathways for preventing DOP and DPN. These results offer promising insights for the development of new therapeutic approaches for diabetic complications.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteoporosis / Polisacáridos / Linfocitos T Reguladores / Rehmannia / Diabetes Mellitus Experimental / Neuropatías Diabéticas Límite: Animals Idioma: En Revista: Int J Biol Macromol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteoporosis / Polisacáridos / Linfocitos T Reguladores / Rehmannia / Diabetes Mellitus Experimental / Neuropatías Diabéticas Límite: Animals Idioma: En Revista: Int J Biol Macromol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos