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Mesoporous polydopamine/copper sulfide hybrid nanocomposite for highly efficient NIR-triggered bacterial inactivation.
Yan, Yunhui; Xu, Na; Wang, Xian; Shi, Li; Huang, Qianqian; Wang, Jia; Li, Xiangrong; Ni, Tianjun; Yang, Zhijun; Guo, Wei.
Afiliación
  • Yan Y; School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, Henan 453003, China; Xinxiang engineering technology research center of functional medicine nanomaterials, Xinxiang Medical University, Xinxiang 453003, China. Electronic address: yanyunhui@xxmu.edu.cn.
  • Xu N; School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, Henan 453003, China; Xinxiang engineering technology research center of functional medicine nanomaterials, Xinxiang Medical University, Xinxiang 453003, China.
  • Wang X; School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, Henan 453003, China; Xinxiang engineering technology research center of functional medicine nanomaterials, Xinxiang Medical University, Xinxiang 453003, China.
  • Shi L; School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, Henan 453003, China; Xinxiang engineering technology research center of functional medicine nanomaterials, Xinxiang Medical University, Xinxiang 453003, China.
  • Huang Q; School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, Henan 453003, China; Xinxiang engineering technology research center of functional medicine nanomaterials, Xinxiang Medical University, Xinxiang 453003, China.
  • Wang J; School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, Henan 453003, China; Xinxiang engineering technology research center of functional medicine nanomaterials, Xinxiang Medical University, Xinxiang 453003, China.
  • Li X; School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, Henan 453003, China; Xinxiang engineering technology research center of functional medicine nanomaterials, Xinxiang Medical University, Xinxiang 453003, China.
  • Ni T; School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, Henan 453003, China; Xinxiang engineering technology research center of functional medicine nanomaterials, Xinxiang Medical University, Xinxiang 453003, China.
  • Yang Z; School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, Henan 453003, China; Xinxiang engineering technology research center of functional medicine nanomaterials, Xinxiang Medical University, Xinxiang 453003, China.
  • Guo W; School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, Henan 453003, China; Xinxiang engineering technology research center of functional medicine nanomaterials, Xinxiang Medical University, Xinxiang 453003, China. Electronic address: 061010@xxmu.edu.cn.
Int J Biol Macromol ; 277(Pt 2): 134238, 2024 Oct.
Article en En | MEDLINE | ID: mdl-39084434
ABSTRACT
Polydopamine has gained considerable attention in the biomaterial domain owing to its excellent biocompatibility, antioxidant activity, photothermal effect and adhesion property. Herein, copper sulfide (Cu2-xS) wrapped in mesoporous polydopamine (MPDA) was synthesized through in-situ polymerization, followed by the surface modification with cationic polyethyleneimine (PEI). The mussel-inspired MPDA matrix successfully prevented the oxidation and agglomeration of Cu2-xS nanoparticles, and regulated the release of copper ions and reactive oxygen species (ROS) levels. Surface-modified PEI endow MPDA@Cu2-xS with positive charges, facilitating their rapid contact with negatively charged bacteria through electrostatic interactions. The pH-dependent Cu+/Cu2+ release and NIR-responsive ROS generation were confirmed using molecular probes and electron spin resonance (ESR). The MPDA@Cu2-xS/PEI showed significantly enhanced antibacterial activity and reduced cytotoxicity for NIH3T3 cells. Under NIR irradiation (1.0 W/cm2, 10 min), germicidal efficiency against Escherichia coli (E. coli) and Staphyloccocus aureus (S. aureus) could reach 100 % and 99.94 %, respectively. The exceptional antibacterial activities of MPDA@Cu2-xS/PEI was mainly attributed to the synergistic photothermal effect, controlled release of copper ions and ROS generation, as well as electrostatic interaction. More importantly, the MPDA@Cu2-xS/PEI composite exhibited excellent biocompatibility and biosafety. Overall, this organic/inorganic hybrid holds great potential as a promising candidate for wound treatment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polímeros / Staphylococcus aureus / Especies Reactivas de Oxígeno / Cobre / Escherichia coli / Nanocompuestos / Indoles / Antibacterianos Límite: Animals Idioma: En Revista: Int J Biol Macromol Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polímeros / Staphylococcus aureus / Especies Reactivas de Oxígeno / Cobre / Escherichia coli / Nanocompuestos / Indoles / Antibacterianos Límite: Animals Idioma: En Revista: Int J Biol Macromol Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos