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Transcranial direct current stimulation improves tardive dyskinesia in long-term hospitalized patients with chronic schizophrenia.
Lyu, Xiaoli; Li, Zhe; Chen, Siyu; Gu, Shuguang; Zhou, Zhaoxin; Yang, Ruchang; Yang, Ping; Zhang, Guangya; Li, Chuanwei; Yuan, Nian; Yin, Ming; Zhang, Wenyue; Wei, Xuexing; Huang, Xiaoxia; Du, Xiangdong.
Afiliación
  • Lyu X; Yangzhou Wutaishan Hospital of Jiangsu Province, Teaching hospital of Yangzhou University, Yangzhou, China; Suzhou Guangji Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, China.
  • Li Z; Suzhou Guangji Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, China.
  • Chen S; Nanchong Psychosomatic Hospital, Nanchong, China.
  • Gu S; The Affiliated Wuxi Mental Health Center of Jiangnan University, Wuxi Central Rehabilitation Hospital, Wuxi, China.
  • Zhou Z; The Affiliated Wuxi Mental Health Center of Jiangnan University, Wuxi Central Rehabilitation Hospital, Wuxi, China.
  • Yang R; Suzhou Guangji Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, China.
  • Yang P; Suzhou Guangji Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, China.
  • Zhang G; Suzhou Guangji Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, China.
  • Li C; Suzhou Guangji Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, China.
  • Yuan N; Suzhou Guangji Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, China.
  • Yin M; Suzhou Guangji Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, China.
  • Zhang W; TaiCang Third People's Hospital, Taicang, China.
  • Wei X; Suzhou Minkang Hospital, Suzhou, China.
  • Huang X; Suzhou Minkang Hospital, Suzhou, China.
  • Du X; Suzhou Guangji Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, China. Electronic address: xiangdong-du@163.com.
Clin Neurophysiol ; 166: 20-30, 2024 Oct.
Article en En | MEDLINE | ID: mdl-39084156
ABSTRACT

OBJECTIVE:

This study aimed to evaluate the efficacy and safety of transcranial direct current stimulation (tDCS) in chronic schizophrenia patients with tardive dyskinesia (TD) who were long-term hospitalized.

METHODS:

Sixty-four inpatients who met the DSM-IV diagnostic criteria for schizophrenia and TD were randomly assigned to either the active (N=35) or sham (N=29) group. Treatment was given 15 times, with each session lasting for 30 min, and an intensity of 2 mA. The anode was placed on the left dorsolateral prefrontal cortex and the cathode on the right supraorbital region. Primary outcome was measured by the changes in Abnormal Involuntary Movements Scale (AIMS) score. Secondary outcomes were measured using the Positive and Negative Syndrome Scale (PANSS) and the Scale for the Assessment of Negative Symptoms (SANS). Adverse effects of tDCS were assessed with an experimenter-administered open-ended questionnaire throughout the experiment.

RESULTS:

Of the 64 patients, 52 (81.25%) completed the study. Compared to the sham group, patients in the active group exhibited a significant reduction in both the total AIMS score and the facial-oral subscore (P<0.05). An improvement of at least 30% in total AIMS scores was observed in the active group (14 patients, 50%) compared to the sham group (2 patients, 8.3%) after treatment (P<0.01). There were no between-group differences in the PANSS and SANS total scores. However, there was a significant difference between the two groups in the occurrence of the reported adverse effect of tingling sensation (P<0.05).

CONCLUSIONS:

TDCS may be an effective and safe treatment for improving the facial-oral motor symptoms of TD in chronically hospitalized patients with schizophrenia.

SIGNIFICANCE:

This study provides a novel perspective for the clinical treatment of patients with TD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Estimulación Transcraneal de Corriente Directa / Discinesia Tardía Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Neurophysiol Asunto de la revista: NEUROLOGIA / PSICOFISIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Estimulación Transcraneal de Corriente Directa / Discinesia Tardía Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Neurophysiol Asunto de la revista: NEUROLOGIA / PSICOFISIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos