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Selenium biomarkers and miR-7-5p in overweight/obese women.
Alves, Higor Paiva de Mendonça; Duarte, Graziela Biude Silva; Souza Junior, Adriano Carlos de; Pereira Batista, Leonam da Silva; Rogero, Marcelo Macedo; Barbosa, Fernando; Cozzolino, Silvia Maria Franciscato; Dantas-Komatsu, Raquel Costa Silva; Marinho Costa, Karina Zaira Silva; Reis, Bruna Zavarize.
Afiliación
  • Alves HPM; Postgraduate Program in Nutrition, Center for Health Sciences, Federal University of Rio Grande do Norte, Rio Grande do Norte, Avenida Senador Salgado Filho, 3000. University Campus - Lagoa Nova, Natal, RN 59078-970, Brazil. Electronic address: higor.paiva.700@ufrn.edu.br.
  • Duarte GBS; Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Science, University of São Paulo, Avenida Prof. Lineu Prestes, 580, Bloco 14 - Butantã, São Paulo, SP 05508-000, Brazil. Electronic address: gbiude@usp.br.
  • Souza Junior AC; Postgraduate Program in Nutrition, Center for Health Sciences, Federal University of Rio Grande do Norte, Rio Grande do Norte, Avenida Senador Salgado Filho, 3000. University Campus - Lagoa Nova, Natal, RN 59078-970, Brazil. Electronic address: adriano.junior.110@ufrn.edu.br.
  • Pereira Batista LDS; Postgraduate Program in Nutrition, Center for Health Sciences, Federal University of Rio Grande do Norte, Rio Grande do Norte, Avenida Senador Salgado Filho, 3000. University Campus - Lagoa Nova, Natal, RN 59078-970, Brazil. Electronic address: leonam.batista.125@ufrn.edu.br.
  • Rogero MM; Department of Nutrition, School of Public Health, University of São Paulo, Avenida Dr. Arnaldo, 715 - Cerqueira César, São Paulo, SP 01246-904, Brazil; Food Research Center (FoRC), CEPID-FAPESP, Research Innovation and Dissemination Centers São Paulo Research Foundation, Laboratory of Food Engineeri
  • Barbosa F; Department of Clinical, Toxicological and Bromatological Analysis, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Avenida do Café, s/nº - Vila Monte Alegre, Ribeirão Preto, SP 14040903, Brazil. Electronic address: fbarbosa@fcfrp.usp.br.
  • Cozzolino SMF; Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Science, University of São Paulo, Avenida Prof. Lineu Prestes, 580, Bloco 14 - Butantã, São Paulo, SP 05508-000, Brazil. Electronic address: smfcozzo@usp.br.
  • Dantas-Komatsu RCS; Postgraduate Program in Pharmaceutical Sciences, Center for Health Sciences, Federal University of Rio Grande do Norte, Rio Grande do Norte, Rua General Gustavo Cordeiro de Faria, s/nº - Petrópolis, Natal, RN 59012-570, Brazil. Electronic address: raquel.komatsu.068@ufrn.edu.br.
  • Marinho Costa KZS; Brazilian Company of Hospital Services (EBSERH), Onofre Lopes University Hospital, Av. Nilo Peçanha, 620 - Petrópolis, Natal, RN 59012-300, Brazil. Electronic address: karina.marinho@ufrn.br.
  • Reis BZ; Postgraduate Program in Nutrition, Center for Health Sciences, Federal University of Rio Grande do Norte, Rio Grande do Norte, Avenida Senador Salgado Filho, 3000. University Campus - Lagoa Nova, Natal, RN 59078-970, Brazil; Department of Nutrition, Federal University of Rio Grande do Norte, Rio Gra
J Trace Elem Med Biol ; 86: 127499, 2024 Jul 20.
Article en En | MEDLINE | ID: mdl-39084121
ABSTRACT

INTRODUCTION:

Chronic low-grade inflammation and oxidative stress are pivotal contributors to the metabolic complications associated with obesity. Selenoprotein P (SELENOP) and glutathione peroxidase 1 (GPx1) are selenoproteins involved in the reduction of reactive oxygen species and pro-inflammatory cytokines levels. Nutritional epigenomics revealed the interaction of microRNAs and nutrients with an important impact on metabolic pathways involved in obesity. However, the knowledge regarding the influence of microRNA on selenium biomarkers and its impact on metabolic pathways related to obesity remains scarce. Thus, the aim of this study was to investigate the association of plasma miR-7-5p expression with selenium and inflammatory biomarkers in women with overweight/obesity. MATERIAL AND

METHODS:

Anthropometric evaluations were performed and blood samples were collected for the analysis of fasting glucose, insulin, inflammatory and selenium biomarkers, and miR-7-5p expression in 54 women with overweight/obesity. Gene expression of SELENOP and GPX1 were evaluated in peripheral mononuclear blood cells.

RESULTS:

This study observed a negative correlation between SELENOP levels and miR-7-5p (rho = -0.350; p = 0.018). Additionally, it was observed that body fat (OR = 0.737; p = 0.011), age (OR = 1.214; p = 0.007), and miR-7-5p (OR = 0.990; p = 0.015) emerged as significant predictors of SELENOP levels.

CONCLUSIONS:

In conclusion, we observed a significant inverse association between miR-7-5p expression and SELENOP concentration in overweight/obese women, suggesting that age and percentage of body fat are also associated. TRIAL REGISTRATION NUMBER Brazilian Registry of Clinical Trials (ReBEC) number RBR-2nfy5q.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Trace Elem Med Biol Asunto de la revista: METABOLISMO / SAUDE AMBIENTAL Año: 2024 Tipo del documento: Article Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Trace Elem Med Biol Asunto de la revista: METABOLISMO / SAUDE AMBIENTAL Año: 2024 Tipo del documento: Article Pais de publicación: Alemania