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Atypical attention and saccade vigor in post-traumatic stress disorder.
Jellestad, Lena; Zeffiro, Thomas; Mörgeli, Hanspeter; Piccirelli, Marco; Jaillard, Assia; Pasi, Patrick; Shepherd, Naomi Ruth; Mueller-Pfeiffer, Christoph.
Afiliación
  • Jellestad L; Department of Consultation-Liaison Psychiatry and Psychosomatic Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland. Electronic address: lena.jellestad@usz.ch.
  • Zeffiro T; University of Maryland School of Medicine, Baltimore, MD, United States; Neurometrika, Potomac, MD, United States.
  • Mörgeli H; Department of Consultation-Liaison Psychiatry and Psychosomatic Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Piccirelli M; Department of Neuroradiology, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Jaillard A; AGEIS, Université Grenoble Alpes (UGA), France; IRM 3T Recherche, IRMaGe, Centre Hospitalier Universitaire Grenoble Alpes (CHUGA), France.
  • Pasi P; Department of Consultation-Liaison Psychiatry and Psychosomatic Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Shepherd NR; Department of Consultation-Liaison Psychiatry and Psychosomatic Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Mueller-Pfeiffer C; Department of Consultation-Liaison Psychiatry and Psychosomatic Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
J Psychiatr Res ; 177: 361-367, 2024 Sep.
Article en En | MEDLINE | ID: mdl-39083994
ABSTRACT
Effective attention control is essential for behavioral adaptation to different environmental contexts. In Post-traumatic Stress Disorder (PTSD) altered attention has been described in trauma-related and other emotional contexts. Nevertheless, atypical attention is also seen with neutral stimuli. The mechanisms of attention alterations in PTSD associated with neutral stimuli are poorly understood. The present study investigates alerting and orienting responses in PTSD participants using emotionally neutral stimuli in a saccade eye movement task incorporating both spatially predictable and temporally unpredictable conditions. We studied 23 PTSD patients and 27 Non-PTSD controls, using repeated-measures mixed modeling to estimate group and task condition differences in behavioral and psychophysiological measures. We explored the relationships among saccade characteristics, pupil size, and PTSD symptoms, including CAPS hypervigilance scores. PTSD, compared to Non-PTSD, participants showed differences in their saccade 'main sequence', reflected by higher peak velocities adjusted for amplitude. PTSD participants had smaller primary position errors in the unpredictable saccade condition. They also exhibited greater hyperarousal, reflected by larger pupil size during fixation that was greater in the unpredictable condition. Our results suggest that a heightened state of arousal and hypervigilance in PTSD leads to a state of atypical attention bias, even in emotionally neutral contexts. These differences may reflect higher saccade vigor. The observed differences suggest atypical attention in PTSD, which goes beyond possible distraction associated with emotional or threat-related stimuli.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Movimientos Sacádicos / Atención / Trastornos por Estrés Postraumático Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Psychiatr Res Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Movimientos Sacádicos / Atención / Trastornos por Estrés Postraumático Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Psychiatr Res Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido