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Sex Differences and Clinical Outcomes in Patients With Myocardial Infarction With Nonobstructive Coronary Arteries: A Meta-Analysis.
Ang, Song P; Chia, Jia E; Krittanawong, Chayakrit; Lee, Kwan; Iglesias, Jose; Misra, Kanchan; Mukherjee, Debabrata.
Afiliación
  • Ang SP; Department of Internal Medicine Rutgers Health/Community Medical Center Toms River NJ.
  • Chia JE; Department of Internal Medicine Texas Tech University Health Science Center El Paso TX.
  • Krittanawong C; Cardiology Division NYU Langone Health and NYU School of Medicine New York NY.
  • Lee K; Department of Cardiovascular Medicine Mayo Clinic Phoenix AZ.
  • Iglesias J; Department of Internal Medicine Rutgers Health/Community Medical Center Toms River NJ.
  • Misra K; Department of Internal Medicine Hackensack Meridian School of Medicine Nutley NJ.
  • Mukherjee D; Department of Radiology Rutgers Robert Wood Johnson Medical School New Brunswick NJ.
J Am Heart Assoc ; 13(15): e035329, 2024 Aug 06.
Article en En | MEDLINE | ID: mdl-39082413
ABSTRACT

BACKGROUND:

Although myocardial infarction with nonobstructive coronary arteries (MINOCA) is more common in women, it is unknown whether sex is a risk factor for adverse outcomes in patients with MINOCA. We aimed to investigate the relationship between sex differences and outcomes of patients with MINOCA. METHODS AND

RESULTS:

A systematic literature search was performed in PubMed, Embase, and Cochrane databases from their inception until August 2023 for relevant studies. End points were pooled using the Hartung-Knapp-Sidik-Jonkman random-effects model as odds ratio (OR) with 95% CIs. Nine studies, involving 30 281 patients with MINOCA (comprising 18 079 women and 12 202 men), were included in the study. Women were older and had a higher prevalence of hypertension, diabetes, and stroke compared with men. The median duration of follow-up was 3.5 years, with an interquartile range of 2.2 to 4.2 years. Pooled analysis revealed no statistically significant difference in the risk of all-cause mortality (OR, 1.03 [95% CI, 0.87-1.22]), major adverse cardiovascular events (OR, 1.18 [95% CI, 0.89-1.58]), heart failure (OR, 1.32 [95% CI, 0.57-3.03]), stroke (OR, 1.13 [95% CI, 0.56-2.26]), and myocardial infarction (OR, 1.04 [95% CI, 0.29-3.76]) between the 2 groups. Regarding short-term outcomes, women had a significantly higher risk of in-hospital major adverse cardiovascular events compared with men (OR, 1.33 [95% CI, 1.16-1.53]) whereas there was no significant difference in the risk of in-hospital mortality (OR, 0.90 [95% CI, 0.64-1.28]) between the 2 patient groups.

CONCLUSIONS:

Despite the differences in demographics and comorbidity profiles, there was no significant difference in the long-term outcomes for patients with MINOCA between sexes. However, it is noteworthy that women experienced a higher risk of in-hospital major adverse cardiovascular events compared with men.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infarto del Miocardio Límite: Female / Humans / Male / Middle aged Idioma: En Revista: J Am Heart Assoc Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infarto del Miocardio Límite: Female / Humans / Male / Middle aged Idioma: En Revista: J Am Heart Assoc Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido