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Ion-sensitive field effect transistor biosensors for biomarker detection: current progress and challenges.
Zou, Jie; Bai, Hao; Zhang, Limei; Shen, Yan; Yang, Chengli; Zhuang, Weihua; Hu, Jie; Yao, Yongchao; Hu, Wenchuang Walter.
Afiliación
  • Zou J; Precision Medicine Translational Research Center (PMTRC), West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China. huwenchuang@wchscu.cn.
  • Bai H; Department of Laboratory Medicine, Clinical Laboratory Medicine Research Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
  • Zhang L; Precision Medicine Translational Research Center (PMTRC), West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China. huwenchuang@wchscu.cn.
  • Shen Y; Department of Laboratory Medicine, Clinical Laboratory Medicine Research Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
  • Yang C; Precision Medicine Translational Research Center (PMTRC), West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China. huwenchuang@wchscu.cn.
  • Zhuang W; Department of Laboratory Medicine, Clinical Laboratory Medicine Research Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
  • Hu J; Precision Medicine Translational Research Center (PMTRC), West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China. huwenchuang@wchscu.cn.
  • Yao Y; Precision Medicine Translational Research Center (PMTRC), West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China. huwenchuang@wchscu.cn.
  • Hu WW; Precision Medicine Translational Research Center (PMTRC), West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China. huwenchuang@wchscu.cn.
J Mater Chem B ; 12(35): 8523-8542, 2024 Sep 11.
Article en En | MEDLINE | ID: mdl-39082127
ABSTRACT
The ion-sensitive field effect transistor (ISFET) has emerged as a crucial sensor device, owing to its numerous benefits such as label-free operation, miniaturization, high sensitivity, and rapid response time. Currently, ISFET technology excels in detecting ions, nucleic acids, proteins, and cellular components, with widespread applications in early disease screening, condition monitoring, and drug analysis. Recent advancements in sensing techniques, coupled with breakthroughs in nanomaterials and microelectronics, have significantly improved sensor performance. These developments are steering ISFETs toward a promising future characterized by enhanced sensitivity, seamless integration, and multifaceted detection capabilities. This review explores the structure and operational principles of ISFETs, highlighting recent research in ISFET biosensors for biomarker detection. It also examines the limitations of these sensors, proposes potential solutions, and anticipates their future trajectory. This review aims to provide a valuable reference for advancing ISFETs in the field of biomarker measurement.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Transistores Electrónicos / Biomarcadores / Técnicas Biosensibles Límite: Humans Idioma: En Revista: J Mater Chem B Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Transistores Electrónicos / Biomarcadores / Técnicas Biosensibles Límite: Humans Idioma: En Revista: J Mater Chem B Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido