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Exploring the role of endogenous retroviruses in seasonal reproductive cycles: a case study of the ERV-V envelope gene in mink.
Zhang, Yufei; Wang, Gaofeng; Zhu, Yanzhu; Cao, Xiaodong; Liu, Fang; Li, Huiping; Liu, Shuying.
Afiliación
  • Zhang Y; College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, China.
  • Wang G; Ulanqab Center for Animal Disease Control and Prevention, Ulanqab, China.
  • Zhu Y; Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun, China.
  • Cao X; School of pharmacy, Inner Mongolia Medical University, Hohhot, China.
  • Liu F; College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, China.
  • Li H; College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, China.
  • Liu S; College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, China.
Front Cell Infect Microbiol ; 14: 1404431, 2024.
Article en En | MEDLINE | ID: mdl-39081866
ABSTRACT

Introduction:

Endogenous retroviruses (ERVs), which originated from exogenous retroviral infections of germline cells millions of years ago and were inherited by subsequent generations as per Mendelian inheritance patterns, predominantly comprise non-protein-coding sequences due to the accumulation of mutations, insertions, deletions, and truncations. Nevertheless, recent studies have revealed that ERVs play a crucial role in diverse biological processes by encoding various proteins.

Methods:

In this study, we successfully identified an ERV envelope (env) gene in a mink species. A phylogenetic tree of mink ERV-V env and reference sequences was constructed using Bayesian methods and maximum-likelihood inference.

Results:

Phylogenetic analyses indicated a significant degree of sequence conservation and positive selection within the env-surface open reading frame. Additionally, qRT-PCR revealed diverse patterns of mink ERV-V env expression in various tissues. The expression of mink ERV-V env gene in testicular tissue strongly correlated with the seasonal reproductive cycles of minks.

Discussion:

Our study suggests that the ERV-V env gene in mink may have been repurposed for host functions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Filogenia / Retrovirus Endógenos / Visón Límite: Animals Idioma: En Revista: Front Cell Infect Microbiol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Filogenia / Retrovirus Endógenos / Visón Límite: Animals Idioma: En Revista: Front Cell Infect Microbiol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza