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Bacillus anthracis in South Africa, 1975-2013: are some lineages vanishing?
Lekota, Kgaugelo Edward; Hassim, Ayesha; Ledwaba, Maphuti Betty; Glover, Barbara A; Dekker, Edgar H; van Schalkwyk, Louis Ockert; Rossouw, Jennifer; Beyer, Wolfgang; Vergnaud, Gilles; van Heerden, Henriette.
Afiliación
  • Lekota KE; Faculty of Veterinary Science, Department of Veterinary Tropical diseases, University of Pretoria, Onderstepoort, 0110, South Africa. 37747959@nwu.ac.za.
  • Hassim A; Unit for Environmental Sciences and Management: Microbiology, North-West University, Potchefstroom campus, Private Bag X6001, Potchefstroom, 2520, South Africa. 37747959@nwu.ac.za.
  • Ledwaba MB; Faculty of Veterinary Science, Department of Veterinary Tropical diseases, University of Pretoria, Onderstepoort, 0110, South Africa.
  • Glover BA; Faculty of Veterinary Science, Department of Veterinary Tropical diseases, University of Pretoria, Onderstepoort, 0110, South Africa.
  • Dekker EH; Department of Agriculture & Animal Health, College of Agriculture & Environmental Sciences, University of South Africa, 28 Pioneer Street, Florida Park, Roodepoort, 1710, South Africa.
  • van Schalkwyk LO; Faculty of Veterinary Science, Department of Veterinary Tropical diseases, University of Pretoria, Onderstepoort, 0110, South Africa.
  • Rossouw J; Department of Agriculture Land Reform and Rural Development, Office of the State Veterinarian, Skukuza, Mpumalanga, 1350, South Africa.
  • Beyer W; Department of Agriculture Land Reform and Rural Development, Office of the State Veterinarian, Skukuza, Mpumalanga, 1350, South Africa.
  • Vergnaud G; Centre for Emerging Zoonotic and Parasitic Diseases, National Institute for Communicable Diseases a Division of the National Health Laboratory Services, Johannesburg, South Africa.
  • van Heerden H; Institute of Environmental and Animal Hygiene, University of Hohenheim, Stuttgart, Germany.
BMC Genomics ; 25(1): 742, 2024 Jul 30.
Article en En | MEDLINE | ID: mdl-39080521
ABSTRACT
The anthrax-causing bacterium Bacillus anthracis comprises the genetic clades A, B, and C. In the northernmost part (Pafuri) of Kruger National Park (KNP), South Africa, both the common A and rare B strains clades occur. The B clade strains were reported to be dominant in Pafuri before 1991, while A clade strains occurred towards the central parts of KNP. The prevalence of B clade strains is currently much lower as only A clade strains have been isolated from 1992 onwards in KNP. In this study 319 B. anthracis strains were characterized with 31-loci multiple-locus variable-number tandem repeat analysis (MLVA-31). B clade strains from soil (n = 9) and a Tragelaphus strepsiceros carcass (n = 1) were further characterised by whole genome sequencing and compared to publicly available genomes. The KNP strains clustered in the B clade before 1991 into two dominant genotypes. South African strains cluster into a dominant genotype A.Br.005/006 consisting of KNP as well as the other anthrax endemic region, Northern Cape Province (NCP), South Africa. A few A.Br.001/002 strains from both endemic areas were also identified. Subclade A.Br.101 belonging to the A.Br.Aust94 lineage was reported in the NCP. The B-clade strains seems to be vanishing, while outbreaks in South Africa are caused mainly by the A.Br.005/006 genotypes as well as a few minor clades such as A.Br.001/002 and A.Br.101 present in NCP. This work confirmed the existence of the rare and vanishing B-clade strains that group in B.Br.001 branch with KrugerB and A0991 KNP strains.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Filogenia / Bacillus anthracis / Carbunco País/Región como asunto: Africa Idioma: En Revista: BMC Genomics Asunto de la revista: GENETICA Año: 2024 Tipo del documento: Article País de afiliación: Sudáfrica Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Filogenia / Bacillus anthracis / Carbunco País/Región como asunto: Africa Idioma: En Revista: BMC Genomics Asunto de la revista: GENETICA Año: 2024 Tipo del documento: Article País de afiliación: Sudáfrica Pais de publicación: Reino Unido