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Electrospun high hydrophilicity antimicrobial poly (lactic acid)/silk fibroin nanofiber membrane for wound dressings.
Fang, Yiqi; Liu, Zixuan; Jin, Yujuan; Huang, Yansong; Zhou, Sudan; Tian, Huafeng; Wu, Hua.
Afiliación
  • Fang Y; School of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing 100048, PR China; Beijing Key Laboratory of Quality Evaluation Technology for Hygiene and Safety of Plastics, Beijing Technology and Business University, Beijing 100048, PR China.
  • Liu Z; School of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing 100048, PR China; Beijing Key Laboratory of Quality Evaluation Technology for Hygiene and Safety of Plastics, Beijing Technology and Business University, Beijing 100048, PR China.
  • Jin Y; School of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing 100048, PR China; Beijing Key Laboratory of Quality Evaluation Technology for Hygiene and Safety of Plastics, Beijing Technology and Business University, Beijing 100048, PR China. Electronic address
  • Huang Y; School of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing 100048, PR China; Beijing Key Laboratory of Quality Evaluation Technology for Hygiene and Safety of Plastics, Beijing Technology and Business University, Beijing 100048, PR China.
  • Zhou S; School of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing 100048, PR China; Beijing Key Laboratory of Quality Evaluation Technology for Hygiene and Safety of Plastics, Beijing Technology and Business University, Beijing 100048, PR China.
  • Tian H; School of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing 100048, PR China; Beijing Key Laboratory of Quality Evaluation Technology for Hygiene and Safety of Plastics, Beijing Technology and Business University, Beijing 100048, PR China. Electronic address
  • Wu H; School of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing 100048, PR China; Beijing Key Laboratory of Quality Evaluation Technology for Hygiene and Safety of Plastics, Beijing Technology and Business University, Beijing 100048, PR China. Electronic address
Int J Biol Macromol ; 277(Pt 1): 133905, 2024 Oct.
Article en En | MEDLINE | ID: mdl-39079839
ABSTRACT
Antimicrobial wound dressings can aid wound healing by preventing bacterial infection. This is particularly true of electrospun ones, which have a porous structure and can be easily loaded with antimicrobial drugs. Here, Poly lactic acid (PLA), Silk Fibroin (SF) and antimicrobial agents of Silver nanoparticles (Ag NPs) and Silver oxide (Ag2O) to prepare the PLA/SF composites antimicrobial nanofiber membrane by electrospinning. The PLA with 30 % SF nanofiber membrane show the water vapor permeability (WVP) and the liquid absorption of 36 g·mm/(m2·d·kPa) and 1721 %. With the increasing of SF contents, the degradation rate and surface hydrophilicity of the nanofiber membrane increase significantly. The nanofiber membrane exhibited excellent antimicrobial activity against Pseudomonas aeruginosa (P. aeruginosa) with the inhibition circle reach at 18.2 mm. The resultant nanofiber membrane showed high cytosolic activity, good cytocompatibility and strong antimicrobial ability, which laid a theoretical foundation for the construction of a new PLA/SF composites antimicrobial fiber membrane.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Poliésteres / Pseudomonas aeruginosa / Vendajes / Nanofibras / Interacciones Hidrofóbicas e Hidrofílicas / Fibroínas / Membranas Artificiales Límite: Animals Idioma: En Revista: Int J Biol Macromol Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Poliésteres / Pseudomonas aeruginosa / Vendajes / Nanofibras / Interacciones Hidrofóbicas e Hidrofílicas / Fibroínas / Membranas Artificiales Límite: Animals Idioma: En Revista: Int J Biol Macromol Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos