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Conjunctival Histopathological Changes and Clinical Tear Film in Children with Atopic Dermatitis.
Bayat, Alper Halil; Aydemir, Gozde Aksoy; Aydemir, Emre; Özkan, Haci Hasan; Yardimci, Gürkan; Türk, Bilge Aydin; Kilinç, Emine Özkul.
Afiliación
  • Bayat AH; Ophthalmology, Bahcesehir University Faculty of Medicine, Besiktas, Turkey.
  • Aydemir GA; Adiyaman University, Traning and Research Hospital, Adiyaman, Turkey.
  • Aydemir E; Adiyaman University, Traning and Research Hospital, Adiyaman, Turkey.
  • Özkan HH; Department of Ophthalmology, Bornova Türkan Özilhan State Hospital, Izmir, Turkey.
  • Yardimci G; Dermatology, Istanbul Medipol University, Istanbul, Turkey.
  • Türk BA; Department of Pathology, Adiyaman University Education and Research Hospital, Adiyaman, Turkey.
  • Kilinç EÖ; Dermatology, Adiyaman University, Adiyaman, Turkey.
Klin Monbl Augenheilkd ; 2024 Aug 27.
Article en En | MEDLINE | ID: mdl-39079701
ABSTRACT

PURPOSE:

Evaluation of changes in the ocular surfaces in children with a diagnosis of atopic dermatitis (AD).

METHODS:

Thirty-six children with a diagnosis of AD (Eye-AD group) and 40 healthy subjects (Eye-HS group) were enrolled in this prospective case-control study. Tear film break-up time (T-BUT), Schirmer tear test (STT), conjunctival impression cytology (CIC), tear meniscus height (TMH), tear meniscus area (TMA), and ocular surface disease index (OSDI) were measured.

RESULTS:

The participants were similar in terms of demographic characteristics, such as mean age and gender (p > 0.05). The mean T-BUT was 9.3 ± 2.22 s (5 - 16) in the Eye-AD group and 11.83 ± 2.03 s (7 - 16) in the Eye-HS group. The mean STT was 11.12 ± 3.28 mm (5 - 21) in the Eye-AD group and 15.44 ± 3.8 mm (8 - 20) in the Eye-HS group (p < 0.001, p < 0.001, respectively). The mean OSDI scores were 13.12 ± 1.41 (10 - 15) in the Eye-AD group and 13.97 ± 2.93 (8 - 20) in the Eye-HS group (p = 0.052). Mean TMH and TMA were 306.48 ± 7.29 µm and 0.22 ± 0.004 mm2, respectively, in the Eye-AD group, and 312.94 ± 5.31 µm and 0.027 ± 0.005 mm2, respectively, in the Eye-HS group. In the CIC analyses, 22 of the samples in the Eye-AD group and 35 in the Eye-HS group had a classification of grade 0, 10 in the Eye-AD group and 5 in the Eye-HS group had a classification of grade 1, and 4 in the Eye-AD group and none in the Eye-HS group had a classification of grade 2 (p = 0.015).

CONCLUSION:

Pediatric patients with AD may have significant changes in conjunctival histopathology. These changes can be manifested in the tests used to measure the tear film. Dry eye was shown to be present in the majority of children with AD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Klin Monbl Augenheilkd Año: 2024 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Klin Monbl Augenheilkd Año: 2024 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Alemania