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In vitro interactions of combinations of colistin with meropenem, rifampicin and tigecycline in colistin-resistant, biofilm-forming Klebsiella pneumoniae.
Müderris, Tuba; Dursun Manyasli, Gülden; Kaya, Selçuk; Gül Yurtsever, Süreyya.
Afiliación
  • Müderris T; Izmir Katip Çelebi University, Faculty of Medicine, Department of Medical Microbiology, Izmir, Türkiye. Electronic address: tubamuderris@yahoo.com.
  • Dursun Manyasli G; Ministry of Health Cizre Dr Selahattin Cizrelioglu State Hospital, Department of Medical Microbiology, Sirnak, Türkiye.
  • Kaya S; Izmir Katip Çelebi University, Faculty of Medicine, Department of Medical Microbiology, Izmir, Türkiye.
  • Gül Yurtsever S; Izmir Katip Çelebi University, Faculty of Medicine, Department of Medical Microbiology, Izmir, Türkiye.
Diagn Microbiol Infect Dis ; 110(2): 116408, 2024 Oct.
Article en En | MEDLINE | ID: mdl-39079190
ABSTRACT
In this study, it was aimed to reveal the in vitro interactions of combinations of colistin with meropenem, rifampicin and tigecycline in colistin-resistant, biofilm-forming Klebsiella pneumonia. A total of 30 isolates, 15 of which formed biofilms and 15 did not form biofilms, were randomly selected from K. pneumoniae isolates growing in blood samples. The synergy rates of colistin-meropenem, colistin-tigecycline, colistin-rifampicin combinations in planktonic/sessile bacteria are; It was determined as 83,3%/73,3%, 66,6%/33,3%, 100%/60% respectively. Biofilm inhibitory concentration (BIC) of colistin, meropenem, tigecycline, and rifampicin significantly increased after biofilm formation. The synergistic activity seen in the sessile form was independent of the planktonic form. Although a high synergistic effect was observed in the meropenem-colistin combination on sessile bacteria, colistin had very high BIC ​​in all combinations. Large-scale studies are needed in which the number of isolates studied is large, bacterial resistance profiles are evaluated genomically, and various antimicrobial groups are included.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Rifampin / Infecciones por Klebsiella / Pruebas de Sensibilidad Microbiana / Colistina / Biopelículas / Sinergismo Farmacológico / Meropenem / Tigeciclina / Klebsiella pneumoniae / Antibacterianos Límite: Humans Idioma: En Revista: Diagn Microbiol Infect Dis Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Rifampin / Infecciones por Klebsiella / Pruebas de Sensibilidad Microbiana / Colistina / Biopelículas / Sinergismo Farmacológico / Meropenem / Tigeciclina / Klebsiella pneumoniae / Antibacterianos Límite: Humans Idioma: En Revista: Diagn Microbiol Infect Dis Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos