Microbial Primer: what is the stringent response and how does it allow bacteria to survive stress?

Urwin, Lucy; Savva, Orestis; Corrigan, Rebecca M

Urwin, Lucy; Savva, Orestis; Corrigan, Rebecca M.

Afiliación

Urwin L; The Florey Institute of Infection, School of Biosciences, University of Sheffield, Sheffield, S10 2TN, UK.
Savva O; The Florey Institute of Infection, School of Biosciences, University of Sheffield, Sheffield, S10 2TN, UK.
Corrigan RM; The Florey Institute of Infection, School of Biosciences, University of Sheffield, Sheffield, S10 2TN, UK.

Microbiology (Reading) ; 170(7)2024 Jul.

Article en En | MEDLINE | ID: mdl-39078282

ABSTRACT

ABSTRACT

The stringent response is a conserved bacterial stress response that allows bacteria to alter their activity and survive under nutrient-limiting conditions. Activation of the stringent response is characterized by the production of intracellular signalling molecules, collectively termed (p)ppGpp, which interact with multiple targets inside bacterial cells. Together, these interactions induce a slow growth phenotype to aid bacterial survival by altering the transcriptomic profile of the cell, inhibiting ribosome biosynthesis and targeting enzymes involved in other key metabolic processes.

Asunto(s)

Bacterias; Regulación Bacteriana de la Expresión Génica; Estrés Fisiológico; Bacterias/metabolismo; Bacterias/genética; Bacterias/crecimiento & desarrollo; Fenómenos Fisiológicos Bacterianos; Transducción de Señal; Viabilidad Microbiana; Guanosina Pentafosfato/metabolismo; Proteínas Bacterianas/metabolismo; Proteínas Bacterianas/genética

Palabras clave

ppGpp; stress; stringent response

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estrés Fisiológico / Bacterias / Regulación Bacteriana de la Expresión Génica Idioma: En Revista: Microbiology (Reading) Asunto de la revista: MICROBIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Reino Unido

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