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Autologous matrix-induced chondrogenesis provides better outcomes in comparison to autologous minced cartilage implantation in the repair of knee chondral defects.
Behrendt, Peter; Eggeling, Lena; Lindner, Anja; von Rehlingen-Prinz, Fidelius; Krause, Matthias; Hoffmann, Michael; Frosch, Karl-Heinz; Akoto, Ralph; Gille, Justus.
Afiliación
  • Behrendt P; Department of Orthopaedics and Traumatology, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany.
  • Eggeling L; Department of Anatomy, Christian-Albrechts-University, Kiel, Germany.
  • Lindner A; Department of Trauma Surgery, Orthopaedics and Sports Traumatology, BG Hospital Hamburg, Hamburg, Germany.
  • von Rehlingen-Prinz F; Department of Trauma Surgery, Orthopedics and Sportsorthopedics, Asklepios St. Georg, Hamburg, Germany.
  • Krause M; Department of Trauma and Orthopaedic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Hoffmann M; Department of Trauma and Orthopaedic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Frosch KH; Department of Trauma Surgery, Orthopedics and Sportsorthopedics, Asklepios St. Georg, Hamburg, Germany.
  • Akoto R; Department of Trauma and Orthopaedic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Gille J; Department of Trauma Surgery, Orthopaedics and Sports Traumatology, BG Hospital Hamburg, Hamburg, Germany.
Knee Surg Sports Traumatol Arthrosc ; 2024 Jul 30.
Article en En | MEDLINE | ID: mdl-39077845
ABSTRACT

PURPOSE:

In symptomatic mid-sized focal chondral defects, autologous matrix-induced chondrogenesis (AMIC) and minced cartilage implantation (MCI) offer two versatile treatment options. This study aimed to conduct a matched-patient analysis of patient-reported outcome measures to compare these two surgical treatment methods for focal chondral defects.

METHODS:

At the first centre, patients underwent a single-stage procedure in which autologous cartilage was hand-minced, implanted into the defect and fixed with fibrin glue. At the second centre, patients underwent AMIC, which was fixed in place with fibrin glue. All patients were seen 2-4 years postoperatively. Postoperative outcomes were assessed using the visual analogue scale for pain (VAS), the Lysholm score and the five domains of the knee osteoarthritis outcome score (KOOS). Patients from each surgical centre were matched by age, sex, defect size and defect localisation.

RESULTS:

In total, 48 patients from two surgical centres (24 from each site) were matched for sex, age (MCI 30.3 ± 14.9 years vs. AMIC 30.8 ± 13.7 years) and defect size (MCI 2.49 ± 1.5 cm2 vs. AMIC 2.65 ± 1.1 cm2). Significantly better scores in the AMIC cohort were noted for VAS (p = 0.004), Lysholm (p = 0.043) and the KOOS subscales for pain (p = 0.016) and quality of life (p = 0.036). There was a significantly greater proportion of positive responders for Lysholm in the AMIC group (92%) compared with the MCI group (64%).

CONCLUSIONS:

The AMIC procedure delivers superior patient outcomes compared with hand-minced autologous cartilage implantation. These are mid-term outcomes, with follow-up between 2 and 4 years. LEVEL OF EVIDENCE Level III.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Knee Surg Sports Traumatol Arthrosc Asunto de la revista: MEDICINA ESPORTIVA / TRAUMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Knee Surg Sports Traumatol Arthrosc Asunto de la revista: MEDICINA ESPORTIVA / TRAUMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Alemania