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Influence of carbonyl cyanide m-chlorophenyl hydrazone on biofilm dynamics, protease, and siderophore production by Burkholderia pseudomallei.
Guedes, Glaucia Morgana de Melo; Ocadaque, Crister José; Amando, Bruno Rocha; Freitas, Alyne Soares; Pereira, Vinicius Carvalho; Cordeiro, Rossana de Aguiar; Bandeira, Silviane Praciano; Souza, Pedro Filho Noronha; Rocha, Marcos Fábio Gadelha; Sidrim, José Júlio Costa; Souza Collares Maia Castelo-Branco, Débora de.
Afiliación
  • Guedes GMM; Department of Pathology and Legal Medicine, Postgraduate Program in Medical Microbiology, Laboratory of Emerging and Reemerging Pathogens, Federal University of Ceará, Fortaleza, Ceará, Brazil.
  • Ocadaque CJ; Department of Pathology and Legal Medicine, Postgraduate Program in Medical Microbiology, Group of Applied Medical Microbiology, Federal University of Ceará, Fortaleza, Ceará, Brazil.
  • Amando BR; Department of Pathology and Legal Medicine, Postgraduate Program in Medical Microbiology, Group of Applied Medical Microbiology, Federal University of Ceará, Fortaleza, Ceará, Brazil.
  • Freitas AS; Department of Pathology and Legal Medicine, Postgraduate Program in Medical Microbiology, Group of Applied Medical Microbiology, Federal University of Ceará, Fortaleza, Ceará, Brazil.
  • Pereira VC; Department of Pathology and Legal Medicine, Postgraduate Program in Medical Microbiology, Group of Applied Medical Microbiology, Federal University of Ceará, Fortaleza, Ceará, Brazil.
  • Cordeiro RA; Department of Pathology and Legal Medicine, Postgraduate Program in Medical Microbiology, Group of Applied Medical Microbiology, Federal University of Ceará, Fortaleza, Ceará, Brazil.
  • Bandeira SP; Department of Pathology and Legal Medicine, Postgraduate Program in Medical Microbiology, Laboratory of Emerging and Reemerging Pathogens, Federal University of Ceará, Fortaleza, Ceará, Brazil.
  • Souza PFN; Department of Pathology and Legal Medicine, Postgraduate Program in Medical Microbiology, Laboratory of Emerging and Reemerging Pathogens, Federal University of Ceará, Fortaleza, Ceará, Brazil.
  • Rocha MFG; Department of Biochemistry and Molecular Biology, Postgraduate Program in Biochemistry, Federal University of Ceará, Fortaleza, Ceará, Brazil.
  • Sidrim JJC; Department of Pathology and Legal Medicine, Postgraduate Program in Medical Microbiology, Laboratory of Emerging and Reemerging Pathogens, Federal University of Ceará, Fortaleza, Ceará, Brazil.
  • Souza Collares Maia Castelo-Branco D; School of Veterinary Medicine, Postgraduate Program in Veterinary Sciences, State University of Ceará, Fortaleza, Ceará, Brazil.
Biofouling ; 40(8): 514-526, 2024 Sep.
Article en En | MEDLINE | ID: mdl-39077794
ABSTRACT
Efflux pump inhibitors are a potential therapeutic strategy for managing antimicrobial resistance and biofilm formation. This article evaluated the effect of carbonyl cyanide m-chlorophenyl hydrazone (CCCP) on the biofilm growth dynamics and the production of virulence factors by Burkholderia pseudomallei. The effects of CCCP on planktonic, growing, and mature biofilm, interaction with antibacterial drugs, and protease and siderophore production were assessed. CCCP MICs ranged between 128 and 256 µM. The CCCP (128 µM) had a synergic effect with all the antibiotics tested against biofilms. Additionally, CCCP reduced (p < .05) the biomass of biofilm growth and mature biofilms at 128 and 512 µM, respectively. CCCP also decreased (p < .05) protease production by growing (128 µM) and induced (p < .05) siderophore release by planktonic cells (128 µM) growing biofilms (12.8 and 128 µM) and mature biofilms (512 µM). CCCP demonstrates potential as a therapeutic adjuvant for disassembling B. pseudomallei biofilms and enhancing drug penetration.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Péptido Hidrolasas / Carbonil Cianuro m-Clorofenil Hidrazona / Pruebas de Sensibilidad Microbiana / Burkholderia pseudomallei / Sideróforos / Biopelículas / Antibacterianos Idioma: En Revista: Biofouling Asunto de la revista: BIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Péptido Hidrolasas / Carbonil Cianuro m-Clorofenil Hidrazona / Pruebas de Sensibilidad Microbiana / Burkholderia pseudomallei / Sideróforos / Biopelículas / Antibacterianos Idioma: En Revista: Biofouling Asunto de la revista: BIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido