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Mesenchymal Stem Cell-Derived Exosomes in Cardioprotection: A Novel Application to Prevent Myocardial Injury.
Yang, Shaokang; Li, Jialin; Tang, Mingbo; Gao, Xinliang; Liu, Wei; Wei, Shixiong.
Afiliación
  • Yang S; Department of Gastric and Colorectal Surgery, General Surgery Center, The First Hospital of Jilin University, 130021 Changchun, Jilin, China.
  • Li J; Department of Thoracic Surgery, The First Hospital of Jilin University, 130021 Changchun, Jilin, China.
  • Tang M; Department of Thoracic Surgery, The First Hospital of Jilin University, 130021 Changchun, Jilin, China.
  • Gao X; Department of Thoracic Surgery, The First Hospital of Jilin University, 130021 Changchun, Jilin, China.
  • Liu W; Department of Thoracic Surgery, The First Hospital of Jilin University, 130021 Changchun, Jilin, China.
  • Wei S; Department of Thoracic Surgery, The First Hospital of Jilin University, 130021 Changchun, Jilin, China.
Rev Cardiovasc Med ; 23(9): 310, 2022 Sep.
Article en En | MEDLINE | ID: mdl-39077717
ABSTRACT
Perioperative myocardial injury is a common complication caused by major surgery. Many pharmacological and nonpharmacological studies have investigated perioperative cardioprotection. However, the methods are insufficient to meet the increasing clinical needs for cardioprotection. The application of Mesenchymal Stem Cell-Derived Exosomes (MSC-Exos) is a novel cell-free therapeutic strategy and has significantly benefitted patients suffering from various diseases. In this review, we comprehensively analyzed the application of MSC-Exos to prevent myocardial infarction/injury by regulating inflammatory reactions, inhibiting cardiomyocyte apoptosis and autophagy, promoting angiogenesis, and mediating cardiac remodeling. Finally, we assessed the therapeutic effects and the challenges associated with the application of MSC-Exos from a clinical perspective.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Rev Cardiovasc Med Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Singapur
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Rev Cardiovasc Med Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Singapur