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Interleukin-6 and Cardiovascular Events in Healthy Adults: MESA.
Khan, Muhammad Shahzeb; Talha, Khawaja M; Maqsood, Muhammad Haisum; Rymer, Jennifer A; Borlaug, Barry A; Docherty, Kieran F; Pandey, Ambarish; Kahles, Florian; Cikes, Maja; Lam, Carolyn S P; Ducharme, Anique; Voors, Adrian A; Hernandez, Adrian F; Lincoff, A Michael; Petrie, Mark C; Ridker, Paul M; Fudim, Marat.
Afiliación
  • Khan MS; Duke University Medical Center, Duke Clinical Research Institute, Durham, North Carolina, USA.
  • Talha KM; Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA.
  • Maqsood MH; Department of Cardiology, DeBakey Heart and Vascular Center, Houston Methodist Hospital, Houston, Texas, USA.
  • Rymer JA; Duke University Medical Center, Duke Clinical Research Institute, Durham, North Carolina, USA.
  • Borlaug BA; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.
  • Docherty KF; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom.
  • Pandey A; Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
  • Kahles F; Department of Internal Medicine I-Cardiology, University Hospital Aachen, Aachen, Germany.
  • Cikes M; University of Zagreb School of Medicine, University Hospital Centre, Zagreb, Croatia.
  • Lam CSP; Duke-NUS Medical School, Singapore, Singapore.
  • Ducharme A; Institut de Cardiologie, de Montréal, Université de Montréal, Montréal, Québec, Canada.
  • Voors AA; Department of Cardiology, University Medical Center of Groningen, University of Groningen, Groningen, the Netherlands.
  • Hernandez AF; Duke University Medical Center, Duke Clinical Research Institute, Durham, North Carolina, USA.
  • Lincoff AM; Heart, Vascular, and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio, USA.
  • Petrie MC; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom.
  • Ridker PM; Center for Cardiovascular Disease Prevention, Division of Preventive Medicine and the Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  • Fudim M; Duke University Medical Center, Duke Clinical Research Institute, Durham, North Carolina, USA.
JACC Adv ; 3(8): 101063, 2024 Aug.
Article en En | MEDLINE | ID: mdl-39077632
ABSTRACT

Background:

Elevated interleukin (IL)-6 levels have been linked to adverse outcomes in patients with and without baseline cardiovascular disease (CVD).

Objectives:

The purpose of this study was to examine the association between circulating IL-6 levels and CVD events without baseline CVD across racial and ethnic groups.

Methods:

We conducted an observational analysis utilizing the MESA (Multi-Ethnic Study of Atherosclerosis), a multicenter, prospective community-based study of CVD at baseline from four racial and ethnic groups. IL-6 levels were measured at the time of enrollment (visit 1) and were divided into 3 terciles. Patient baseline characteristics and outcomes, including all-cause mortality, CV mortality, heart failure, and non-CV mortality, were included. Cox proportional hazard regression models were used to assess associations between IL-6 levels and study outcomes with IL-6 tercile 1 as reference.

Results:

Of 6,622 individuals, over half were women (53%) with a median age of 62 (IQR 53-70) years. Racial and ethnic composition was non-Hispanic White (39%) followed by African American (27%), Hispanic (22%), and Chinese American (12%). Compared to tercile 1, participants with IL-6 tercile 3 had a higher adjusted risk of and all-cause mortality (HR 1.98 [95% CI 1.67-2.36]), CV mortality (HR 1.55 [95% CI 1.05-2.30]), non-CV mortality (HR 2.05 [95% CI 1.65-2.56]), and heart failure (HR 1.48 [95% CI 0.99-2.19]). When tested as a continuous variable, higher levels of IL-6 were associated with an increased risk of all individual outcomes. Compared to non-Hispanic White participants, the unadjusted and adjusted risk of all outcomes across all races and ethnicities was similar across all IL-6 terciles.

Conclusions:

High levels of circulating IL-6 are associated with worse CV outcomes and increased all-cause mortality consistently across all racial and ethnic groups.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: JACC Adv Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: JACC Adv Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos