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Towards a 'clicked' PSMA targeting gene delivery bioconjugate-polyplex for prostate cancer.
Noble, Amanda R; Akkad, Saeed; Yates, Nicholas D J; Jeffries, James M; Signoret, Nathalie; Fascione, Martin A.
Afiliación
  • Noble AR; Department of Chemistry, University of York Heslington York YO10 5DD UK martin.fascione@york.ac.uk.
  • Akkad S; Department of Chemistry, University of York Heslington York YO10 5DD UK martin.fascione@york.ac.uk.
  • Yates NDJ; Department of Chemistry, University of York Heslington York YO10 5DD UK martin.fascione@york.ac.uk.
  • Jeffries JM; Department of Chemistry, University of York Heslington York YO10 5DD UK martin.fascione@york.ac.uk.
  • Signoret N; Hull York Medical School, University of York York YO10 5DD UK nathalie.signoret@york.ac.uk.
  • Fascione MA; Department of Chemistry, University of York Heslington York YO10 5DD UK martin.fascione@york.ac.uk.
RSC Adv ; 14(33): 23796-23801, 2024 Jul 26.
Article en En | MEDLINE | ID: mdl-39077324
ABSTRACT
Prostate cancer is the most common cancer in men in the UK with over 50 000 new cases diagnosed each year and although therapeutic advances in surgery, anti-androgens, radio- and chemotherapy have increased survival rates, there still remains a need for new treatments to combat the most aggressive forms of the disease. Gene therapy offers promise as an alternative approach but is reliant on selective targeting to the cancer cell surface. Herein we describe the novel construction of a prostate specific membrane antigen (PSMA) binding bioconjugate-polyplex, based on a glutamate-urea peptide scaffold using 'click' chemistry, which we demonstrate is capable of targeted delivery of a GFP gene to PSMA overexpressing prostate cancer cells, and therefore may have potential future application as part of a prostate cancer gene delivery therapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: RSC Adv Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: RSC Adv Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido