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A rare presentation of acute-onset chronic inflammatory demyelinating polyneuropathy with the detection of anti-GM3 and anti-sulfatides antibodies: a case report.
Sun, Ruohan; Meng, Yao; Li, Lingyu; Chen, Wei-Hong; Xu, Jing; Lv, Peiyuan; Dong, Yanhong.
Afiliación
  • Sun R; Department of Neurology, Hebei General Hospital, Shijiazhuang, China.
  • Meng Y; Department of Neurology, Hebei Medical University, Shijiazhuang, Hebei, China.
  • Li L; Department of Neurology, Hebei North University, Zhangjiakou, Hebei, China.
  • Chen WH; Affiliated Hospital of North China University of Science and Technology, Tangshan, Hebei, China.
  • Xu J; Department of Neurology, Hebei General Hospital, Shijiazhuang, China.
  • Lv P; Department of Neurology, Hebei General Hospital, Shijiazhuang, China.
  • Dong Y; Department of Neurology, Hebei General Hospital, Shijiazhuang, China.
Front Immunol ; 15: 1409637, 2024.
Article en En | MEDLINE | ID: mdl-39076987
ABSTRACT

Objectives:

Chronic inflammatory demyelinating polyneuropathy (CIDP) is an acquired immune-mediated neuropathy defined by clinical progression for more than 2 months. 16-20% of CIDP patients may present with rapidly progressive weakness that resembles GBS, known as acute-onset CIDP (A-CIDP). However, it is challenging to distinguish from GBS-TRF because of their similar clinical symptom and features. In this case review, we report a patient with A-CIDP with the detection of anti-GM3 and anti-sulfatides antibodies, which rarely have been in A-CIDP and may account for her progressive and recurrent symptoms.

Methods:

We analyzed existing medical literature and described a clinical case of A-CIDP with antibodies positive.

Results:

We reported a 56-year-old female presented with bilateral lower extremity weakness and distal numbness. She experienced similar symptoms four times and responded well to the IVIg therapy. Lumbar puncture demonstrated albumin-cytologic dissociation and EDX examination revealed multiple peripheral nerve damage. After ruling out other demyelination diseases, a diagnosis of A-CIDP was made.

Discussion:

The antiganglioside and anti-sulfatide antibodies are involved in CIDP pathogenesis and can help to distinguish A-CIDP and other variants. To prevent secondary damage, it is important to monitor relapse and remission symptoms along the treatment line. A rare case of A-CIDP is discussed concerning the detection of anti-GM3 and anti-sulfatides antibodies, thus making a retrospective comparison of antibodies in some literature to understand A-CIDP better.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autoanticuerpos / Polirradiculoneuropatía Crónica Inflamatoria Desmielinizante / Gangliósido G(M3) Límite: Female / Humans / Middle aged Idioma: En Revista: Front Immunol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autoanticuerpos / Polirradiculoneuropatía Crónica Inflamatoria Desmielinizante / Gangliósido G(M3) Límite: Female / Humans / Middle aged Idioma: En Revista: Front Immunol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza