Synthesis and application of chiral <i>cis</i>-2,5-disubstituted pyrrolidine organocatalysts.

Singh, Suraj; Kumar, Rohtash; Dubey, Navneet Nandgopal; Appayee, Chandrakumar

Synthesis and application of chiral cis-2,5-disubstituted pyrrolidine organocatalysts.

Singh, Suraj; Kumar, Rohtash; Dubey, Navneet Nandgopal; Appayee, Chandrakumar.

Afiliación

Singh S; Department of Chemistry, Indian Institute of Technology Gandhinagar, Palaj, Gandhinagar, Gujarat 382055, India. a.chandra@iitgn.ac.in.
Kumar R; Department of Chemistry, Indian Institute of Technology Gandhinagar, Palaj, Gandhinagar, Gujarat 382055, India. a.chandra@iitgn.ac.in.
Dubey NN; Department of Chemistry, Indian Institute of Technology Gandhinagar, Palaj, Gandhinagar, Gujarat 382055, India. a.chandra@iitgn.ac.in.
Appayee C; Department of Chemistry, Indian Institute of Technology Gandhinagar, Palaj, Gandhinagar, Gujarat 382055, India. a.chandra@iitgn.ac.in.

Chem Commun (Camb) ; 60(66): 8768-8771, 2024 Aug 13.

Article en En | MEDLINE | ID: mdl-39076133

ABSTRACT

ABSTRACT

The first synthesis of chiral cis-2,5-disubstituted pyrrolidine organocatalysts is described. Their application for the enantioselective Michael addition of nitromethane to α,ß-unsaturated aldehydes with excellent yield (up to 91%) and enantioselectivity (up to >99% ee) is demonstrated. Another catalytic application for the reaction of 2,4-hexadienal with nitrostyrene is also showcased.

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Reino Unido

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