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Renal cell carcinoma in a transplanted kidney: a retrospective evaluation.
Trushkin, Ruslan N; Isaev, Teymur K; Medvedev, Pavel E; Shcheglov, Nikolai E; Variasin, Valerii V; Lysenko, Mariana A; Dmitriev, Ilya V; Balkarov, Aslan G; Kesaeva, Laura A.
Afiliación
  • Trushkin RN; Department of Urology, Moscow City Clinical Hospital № 52 of Moscow Healthcare Department, Moscow, Russian Federation.
  • Isaev TK; Department of Urology, Moscow City Clinical Hospital № 52 of Moscow Healthcare Department, Moscow, Russian Federation.
  • Medvedev PE; Department of Urology, Moscow City Clinical Hospital № 52 of Moscow Healthcare Department, Moscow, Russian Federation.
  • Shcheglov NE; Department of Urology, Moscow City Clinical Hospital № 52 of Moscow Healthcare Department, Moscow, Russian Federation.
  • Variasin VV; Department of Urology, Moscow City Clinical Hospital № 52 of Moscow Healthcare Department, Moscow, Russian Federation.
  • Lysenko MA; Department of Urology, Moscow City Clinical Hospital № 52 of Moscow Healthcare Department, Moscow, Russian Federation.
  • Dmitriev IV; Department of Kidney and Pancreas transplantation, Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department, 3 Bol'shaya Sukharevskaya Sq., Moscow, 129090, Russian Federation. dr.ildmi@gmail.com.
  • Balkarov AG; Chair of Transplantology and Artificial Organs, Department of Continuous Medical Education, Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russian Federation. dr.ildmi@gmail.com.
  • Kesaeva LA; Department of Kidney and Pancreas transplantation, Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department, 3 Bol'shaya Sukharevskaya Sq., Moscow, 129090, Russian Federation.
BMC Nephrol ; 25(1): 237, 2024 Jul 29.
Article en En | MEDLINE | ID: mdl-39075385
ABSTRACT

INTRODUCTION:

Kidney transplantation is the optimal treatment modality for patients with end-stage chronic kidney disease. The long-term mortality of kidney recipients is 48-82% lower than that of patients on the waiting list. However, the risk of developing malignancies in these patients is twice as high as in the healthy population. Specifically, the incidence of renal cell carcinoma (RCC) in transplant recipients is 10-30 times higher than in non-transplanted patients. The reason for the increased risk is poorly understood, but is most likely related to continuous immunosuppressive therapy. The problem of kidney graft neoplasia has not been adequately addressed in the medical literature.

OBJECTIVE:

To determine the incidence of renal cell carcinoma in transplanted kidneys, enhance the efficacy of its treatment, and study the etiology of RCC development. MATERIALS AND

METHODS:

A retrospective analysis of RCC incidence in kidney grafts was conducted in 3,270 patients who underwent kidney transplantation between 2013 and 2023. We evaluated the effectiveness of surgical interventions for these complications. Patients with histologically confirmed RCC of the transplanted kidney underwent genetic study to determine the etiology of the neoplasm.

RESULTS:

The incidence of RCC in transplanted kidneys was found to be 0.95% (n = 31), 28 patients underwent laparoscopic resection of the renal transplant tumor, 2 patients were treated with radiofrequency ablation of the tumor. Transplantectomy was performed in 1 patient.

CONCLUSION:

Laparoscopic resection is an effective and safe method for the treatment of RCC in kidney transplants. Transplanted kidney cancer originates from the donor tissue. The clear cell variant of transplanted kidney cancer is a genetically determined disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Células Renales / Trasplante de Riñón / Neoplasias Renales Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: BMC Nephrol Asunto de la revista: NEFROLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Células Renales / Trasplante de Riñón / Neoplasias Renales Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: BMC Nephrol Asunto de la revista: NEFROLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido