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Association between prescription opioid use and heart failure: Cohort studies and Mendelian randomization analysis.
Hao, Guang; Chen, Xia; Fang, Zhenger; He, Yunbiao; Liu, Mingliang; Arora, Vishal; Dua, Anterpreet; Sun, Zhuo; Zhou, Biying; Zheng, Guangjun; Zuo, Lei; Chen, Haiyan; Zhu, Haidong; Dong, Yanbin.
Afiliación
  • Hao G; School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China. Electronic address: haoguang2015@hotmail.com.
  • Chen X; Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, China.
  • Fang Z; Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, China.
  • He Y; Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, China.
  • Liu M; Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, China.
  • Arora V; Department of Medicine: Cardiology, Medical College of Georgia, Augusta University, Augusta, GA, USA.
  • Dua A; Department of Anesthesiology and Perioperative Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA.
  • Sun Z; Department of Anesthesiology and Perioperative Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA.
  • Zhou B; Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, China.
  • Zheng G; Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, China.
  • Zuo L; Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, China.
  • Chen H; Control and Prevention, Guangzhou Center for Disease Control and Prevention, Guangzhou, China.
  • Zhu H; Georgia Prevention Institute, Department of Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA.
  • Dong Y; Georgia Prevention Institute, Department of Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA. Electronic address: ydong@augusta.edu.
Int J Cardiol ; 413: 132404, 2024 Oct 15.
Article en En | MEDLINE | ID: mdl-39074619
ABSTRACT

BACKGROUND:

Prescription opioid use (POU) has been shown to lead to cardiovascular disease (CVD), but its association with heart failure has not been well studied. We investigated the potential causal association between POU and HF using cohort studies and Mendelian Randomization (MR) analysis.

METHODS:

Initially, we examined the longitudinal association between POU and HF using the data from the Health and Retirement Study (HRS) and the UK biobank. Next, we employed a two-sample MR analysis using summary statistics from genome-wide association studies (GWAS) to assess the potential causal associations between POU and HF.

RESULTS:

During a median of 3.8 and 13.8 years of follow-up, there were 441(8.04 per 1000 person-year) and 16,170 (3.96 per 1000 person-year) HF cases in the HRS and the UK biobank, respectively. After adjusting for covariates, participants who used prescription opioids had a 32% increased risk of developing HF, compared with non-users (HR = 1.32, 95%CI 1.26-1.38, P < 0.001). In the MR analysis, summary statistics for POU were obtained from 78,808 UK Biobank study participants, and summary data for HF were obtained from 218,792 participants of a European population. A causal effect of genetic liability for POU on an increased risk of HF (OR = 1.16, 95% CI = 1.06, 1.27, P = 0.001) was suggested. The results were generally consistent in the sensitivity analysis, and no pleiotropy or heterogeneity were observed.

CONCLUSIONS:

POU is associated with a high risk of HF. Our findings provide new insight into prescription opioid use among populations at risk of heart failure. More studies are needed to validate our results and further investigate the underlying mechanisms.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Análisis de la Aleatorización Mendeliana / Insuficiencia Cardíaca / Analgésicos Opioides Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Int J Cardiol Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Análisis de la Aleatorización Mendeliana / Insuficiencia Cardíaca / Analgésicos Opioides Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Int J Cardiol Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos