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The 1-min sit-to-stand test as a screening tool to assess exercise-induced oxygen desaturation in normoxemic people with interstitial lung disease.
Visser, Simone; Lawler, Chloe; Fermoyle, Caitlin C; Spencer, Lissa M; McAnulty, Amanda J; Alison, Jennifer A; Webster, Susanne; Troy, Lauren; Jo, Helen; Hayen, Andrew; Corte, Tamera J.
Afiliación
  • Visser S; Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, Sydney, Australia; University of Sydney, Faculty of Medicine and Health, Sydney, Australia. Electronic address: simone.visser@health.nsw.gov.au.
  • Lawler C; Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, Sydney, Australia; University of Sydney, Faculty of Medicine and Health, Sydney, Australia; Centre of Research Excellence in Pulmonary Fibrosis, Australia.
  • Fermoyle CC; Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, Sydney, Australia; University of Sydney, Faculty of Medicine and Health, Sydney, Australia; Centre of Research Excellence in Pulmonary Fibrosis, Australia.
  • Spencer LM; Department of Physiotherapy, Royal Prince Alfred Hospital, Sydney, Australia.
  • McAnulty AJ; Department of Physiotherapy, Royal Prince Alfred Hospital, Sydney, Australia.
  • Alison JA; University of Sydney, Faculty of Medicine and Health, Sydney, Australia; Allied Health, Sydney Local Health District, Sydney, Australia.
  • Webster S; Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, Sydney, Australia.
  • Troy L; Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, Sydney, Australia; University of Sydney, Faculty of Medicine and Health, Sydney, Australia; Centre of Research Excellence in Pulmonary Fibrosis, Australia.
  • Jo H; Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, Sydney, Australia; University of Sydney, Faculty of Medicine and Health, Sydney, Australia.
  • Hayen A; School of Public Health, University of Technology Sydney, Sydney, Australia.
  • Corte TJ; Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, Sydney, Australia; University of Sydney, Faculty of Medicine and Health, Sydney, Australia; Centre of Research Excellence in Pulmonary Fibrosis, Australia.
Respir Med ; 232: 107748, 2024 Oct.
Article en En | MEDLINE | ID: mdl-39074595
ABSTRACT

BACKGROUND:

In patients with interstitial lung disease (ILD), exercise-induced desaturation during the 6-min walk test (6MWT), specifically nadir oxygen saturation (nSpO2) of ≤88 % is a negative prognostic marker. As the 6MWT is often impractical for ILD patients, the aim of this study is to compare the 1-min sit-to-stand test (1minSTS) with the 6MWT to detect exercise-induced desaturation.

METHODS:

Participants were recruited from a tertiary referral clinic with both tests performed on the same day. Utilising Bland-Altman analysis, the relationship between nSpO2 on 1minSTS and 6MWT was determined. An area under the receiver operating characteristic curve (AUC) determined the ability of nSpO2 on 1minSTS test to predict SpO2 ≤88 % on 6MWT.

RESULTS:

Fifty participants completed the study (idiopathic pulmonary fibrosis n = 24, 48 %; connective tissue disease associated ILD n = 20, 40 %; other ILD n = 6, 12 %). Mean (SD) FVC%pred was 73 ± 16 %, mean DLCO%pred 57 ± 16 % and resting SpO2 99 ± 1 %. The 1minSTS resulted in less exercise-induced oxygen desaturation, with a median IQR nSpO2 of 95 % (89-98) and 93 % (85-96) respectively (p < 0.001). Moderate agreement was determined between the nSpO2 on both tests, with a mean difference of 3.2 % [-14 to +3.0 %]. The 1minSTS test accurately identified participants with nSpO2 ≤88 % on 6MWT (AUC 0.96). Oxygen desaturation ≤94 % during the 1minSTS test provided 100 % sensitivity and 87 % specificity for oxygen desaturation ≤88 % at 6MWT.

CONCLUSION:

This study demonstrates that exercise-induced oxygen desaturation during the 1minSTS test correlates with oxygen desaturation on 6MWT. The 1minSTS may be a practical screening tool for ILD patients who would benefit from further exercise testing.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Pulmonares Intersticiales / Prueba de Esfuerzo / Prueba de Paso / Saturación de Oxígeno Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Respir Med Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Pulmonares Intersticiales / Prueba de Esfuerzo / Prueba de Paso / Saturación de Oxígeno Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Respir Med Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido