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"All-in-one" metal polyphenol network nanocapsules integrated microneedle patches for lipophagy fueled ferroptosis-mediated multimodal therapy.
Wang, Wenhao; Zhong, Ziqiao; Peng, Siyuan; Fu, Jintao; Chen, Minglong; Lang, Tianqun; Yue, Xiao; Fu, Yanping; He, Jingyu; Jin, Yuzhen; Huang, Ying; Wu, Chuanbin; Huang, Zhengwei; Pan, Xin.
Afiliación
  • Wang W; School of Pharmaceutical Science, Sun Yat-Sen University, Guangzhou 510006, China. Electronic address: wangwh37@mail2.sysu.edu.cn.
  • Zhong Z; College of Pharmacy, Jinan University, Guangzhou 511443, China; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou 511443, China. Electronic address: zhongzq@stu2022.jnu.edu.cn.
  • Peng S; School of Pharmaceutical Science, Sun Yat-Sen University, Guangzhou 510006, China. Electronic address: pengsy23@mail2.sysu.edu.cn.
  • Fu J; School of Pharmaceutical Sciences, Hainan University, Haikou 570228, China. Electronic address: fujintao@hainanu.edu.cn.
  • Chen M; CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei 230026, China. Electronic address: minglchen@mail.ustc.edu.cn.
  • Lang T; Lingang Laboratory, Shanghai 200031, China. Electronic address: langtq@lglab.ac.cn.
  • Yue X; College of Pharmacy, Jinan University, Guangzhou 511443, China; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou 511443, China.
  • Fu Y; College of Pharmacy, Jinan University, Guangzhou 511443, China; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou 511443, China. Electronic address: fuyanping@stu2021.jnu.edu.cn.
  • He J; College of Pharmacy, Jinan University, Guangzhou 511443, China; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou 511443, China. Electronic address: wdhjy@stu2021.jnu.edu.cn.
  • Jin Y; College of Pharmacy, Jinan University, Guangzhou 511443, China; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou 511443, China.
  • Huang Y; College of Pharmacy, Jinan University, Guangzhou 511443, China; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou 511443, China.
  • Wu C; College of Pharmacy, Jinan University, Guangzhou 511443, China; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou 511443, China.
  • Huang Z; College of Pharmacy, Jinan University, Guangzhou 511443, China; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou 511443, China. Electronic address: huangzhengw@jnu.edu.cn.
  • Pan X; School of Pharmaceutical Science, Sun Yat-Sen University, Guangzhou 510006, China. Electronic address: panxin2@mail.sysu.edu.cn.
J Control Release ; 373: 599-616, 2024 Sep.
Article en En | MEDLINE | ID: mdl-39074587
ABSTRACT
Ferroptosis-mediated multimodal therapy has emerged as a promising strategy for tumor elimination, with lipid peroxide (LPO) playing a pivotal role. However, the therapeutic efficiency is limited due to insufficient intracellular levels of free fatty acids (FFA), which severely hinder the production of LPO. To address this limitation, we proposed a lipophagy strategy aimed at degrading lipid droplets (LDs) to release FFA, serving as the essential "fuel" for LPO production. In this study, the lipophagy inducer epigallocatechin gallate (EGCG) was self-assembled with reactive oxygen species (ROS)-producer phenethyl isothiocyanate (PEITC) mediated by Fe2+ to form EFP nanocapsules, which were further integrated into microneedle patches to form a "all-in-one" EFP@MNs. The metal-polyphenol network structure of EFP endow it with photothermal therapy capacity. Upon insertion into tumors, the released EFP nanocapsules were demonstrated to induce lipophagy through metabolic disturbance, thereby promoting LPO production and facilitating ferroptosis. When combined with photothermal therapy, this approach significantly remolded the tumor immune microenvironment by driving tumor-associated macrophages toward M1 phenotype and enhancing dendritic cell maturation. Encouragingly, in conjunction with αPD-L1 treatment, the proposed EFP@MNs exhibited remarkable efficacy in tumor ablation. Our study presents a versatile framework for utilizing microneedle patches to power ferroptosis-mediated multimodal therapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nanocápsulas / Polifenoles / Ferroptosis Límite: Animals / Female / Humans Idioma: En Revista: J Control Release Asunto de la revista: FARMACOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nanocápsulas / Polifenoles / Ferroptosis Límite: Animals / Female / Humans Idioma: En Revista: J Control Release Asunto de la revista: FARMACOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos