Your browser doesn't support javascript.
loading
RBE-based dose planning, and calculation of TCP and NTCP with gold nanoparticles for intermediate photon energy in pancreatic cancer.
Khaledi, Navid; Karshafian, Raffi; Taggar, Amandeep S; Alrabiah, Khalid; Khan, Rao; Gräfe, James L.
Afiliación
  • Khaledi N; Department of Physics, Toronto Metropolitan University, Toronto, ON M5B 2K3, Canada.
  • Karshafian R; Department of Medical Physics, CancerCare Manitoba, Winnipeg, MB, Canada.
  • Taggar AS; Department of Physics, Toronto Metropolitan University, Toronto, ON M5B 2K3, Canada.
  • Alrabiah K; Institute for Biomedical Engineering, Science and Technology (iBEST), A Partnership Between Toronto Metropolitan University and St. Michael's Hospital, 209 Victoria Street, Toronto, ON M5B 1T8, Canada.
  • Khan R; Keenan Research Centre for Biomedical Science, Unity Health Toronto, 209 Victoria Street, Toronto, ON M5B 1W8, Canada.
  • Gräfe JL; Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Odette Cancer Centre, University of Toronto, Toronto, ON, Canada.
Phys Med Biol ; 69(17)2024 Aug 14.
Article en En | MEDLINE | ID: mdl-39074499
ABSTRACT
Objective.This study simulated the potential of gold nanoparticles (GNPs) to improve the effectiveness of radiation therapy in pancreatic cancer cases. The purpose of this study was to assess the impact of GNPs on tumor control probability (TCP) and normal tissue complication probability (NTCP) in pancreatic cancer cases undergoing radiation therapy. The work aimed to compare treatment plans generated with a novel 2.5 MV beam using GNPs to conventional 6 MV plans and evaluate the dose-volume histogram (DVH), TCP, and NTCP.Approach.Treatment planning for five pancreatic computed tomography (CT) images was performed using the open-source MATLAB-based treatment planning program matRad. MATLAB codes were developed to calculate the relative biological effectiveness (RBE) of GNPs and apply the corresponding dose and RBE values to each voxel. TCP and NTCP were calculated based on the applied RBE values.Main results.Adding GNPs to the 2.5 MV treatment plan resulted in a significant increase in TCP, from around 59% to 93.5%, indicating that the inclusion of GNPs improved the effectiveness of the radiation treatment. The range in NTCP without GNPs was relatively larger compared to that with GNPs.Significance.The results indicated that the addition of GNPs to a 2.5 MV plan can increase TCP while maintaining a relatively low NTCP value (<1%). The use of GNPs may also reduce NTCP values by decreasing the dose to normal tissues while maintaining the same prescribed dose to the tumor. Hence, the addition of GNPs can improve the balance between TCP and NTCP.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Dosificación Radioterapéutica / Planificación de la Radioterapia Asistida por Computador / Fotones / Nanopartículas del Metal / Oro Límite: Humans Idioma: En Revista: Phys Med Biol Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Dosificación Radioterapéutica / Planificación de la Radioterapia Asistida por Computador / Fotones / Nanopartículas del Metal / Oro Límite: Humans Idioma: En Revista: Phys Med Biol Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido