Your browser doesn't support javascript.
loading
Combined peripheral blood monocyte count and white blood cell count as a guide for successful one-day autologous peripheral blood stem cell collection.
Watanaboonyongcharoen, Phandee; Lorucharoen, Nattarat; Wudhikarn, Kitsada; Bunworasate, Udomsak; Chanswangphuwana, Chantiya; Rojnuckarin, Ponlapat.
Afiliación
  • Watanaboonyongcharoen P; Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
  • Lorucharoen N; Transfusion Medicine Unit, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
  • Wudhikarn K; Renal Immunology and Renal Transplant Research Unit, Chulalongkorn University, Bangkok, Thailand.
  • Bunworasate U; Center of Excellence in Translational Hematology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
  • Chanswangphuwana C; Transfusion Medicine Unit, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
  • Rojnuckarin P; Center of Excellence in Translational Hematology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Int J Lab Hematol ; 2024 Jul 29.
Article en En | MEDLINE | ID: mdl-39074488
ABSTRACT

INTRODUCTION:

Peripheral blood stem cells (PBSCs) are the most common source of stem cell transplantation, which depends on an adequate number of CD34+ cells. Although pre-apheresis CD34+ cell count is a standard guide for the collection, it is not always available. This study aimed to evaluate complete blood count parameters for predicting successful one-day autologous PBSC collection.

METHODS:

Data from the patients who underwent autologous PBSC collection at a tertiary care hospital were retrospectively reviewed.

RESULTS:

There were 123 patients (185 leukapheresis procedures). Successful PBSC collection (CD34+ cells ≥4.0 × 106 cells/kg) was obtained in 85 patients (69.1%), of which 55 (44.7%) were successfully obtained on the first day. The median CD34+ collection efficiency was 44.1%. The mean platelet loss during apheresis was 39.9%. The adverse event rate was 18.9%. Patients in whom PBSCs were collected within one day were less likely to experience adverse effects related to leukapheresis. Pre-apheresis CD34+ cells ≥10 cells/µLand combined white blood cell (WBC) counts ≥5 × 109/L and/or monocyte ≥10% were independently associated with the successful one-day PBSC collection (adjusted odds ratio 24.06, 95% confidence interval [CI] 5.30-109.10, p < 0.001; and 6.94, 95% CI 1.35-35.79, p = 0.021, respectively). Only pre-apheresis CD34+ cells had a strong correlation with the total stem cell yield.

CONCLUSIONS:

To reduce the complication of leukapheresis, the combined pre-apheresis WBC ≥5 × 109/L and/or monocyte ≥10% is a practical parameter to initiate a successfully one-day PBSC collection with or without pre-apheresis CD34+ cell results.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Int J Lab Hematol Asunto de la revista: HEMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Tailandia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Int J Lab Hematol Asunto de la revista: HEMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Tailandia Pais de publicación: Reino Unido