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Toward real-time, volumetric dosimetry for FLASH-capable clinical synchrocyclotrons using protoacoustic imaging.
Wang, Siqi; Gonzalez, Gilberto; Owen, Daniel Rocky; Sun, Leshan; Liu, Yan; Zwart, Townsend; Chen, Yong; Xiang, Liangzhong.
Afiliación
  • Wang S; The Department of Biomedical Engineering, University of California, Irvine, California, USA.
  • Gonzalez G; Department of Radiation Oncology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
  • Owen DR; Mevion Medical Systems, Littleton, Massachusetts, USA.
  • Sun L; The Department of Biomedical Engineering, University of California, Irvine, California, USA.
  • Liu Y; Mevion Medical Systems, Littleton, Massachusetts, USA.
  • Zwart T; Mevion Medical Systems, Littleton, Massachusetts, USA.
  • Chen Y; Department of Radiation Oncology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
  • Xiang L; The Department of Biomedical Engineering, University of California, Irvine, California, USA.
Med Phys ; 51(11): 8496-8505, 2024 Nov.
Article en En | MEDLINE | ID: mdl-39073707
ABSTRACT

BACKGROUND:

Radiation delivery with ultra-high dose rate (FLASH) radiotherapy (RT) holds promise for improving treatment outcomes and reducing side effects but poses challenges in radiation delivery accuracy due to its ultra-high dose rates. This necessitates the development of novel imaging and verification technologies tailored to these conditions.

PURPOSE:

Our study explores the effectiveness of proton-induced acoustic imaging (PAI) in tracking the Bragg peak in three dimensions and in real time during FLASH proton irradiations, offering a method for volumetric beam imaging at both conventional and FLASH dose rates.

METHODS:

We developed a three-dimensional (3D) PAI technique using a 256-element ultrasound detector array for FLASH dose rate proton beams. In the study, we tested protoacoustic signal with a beamline of a FLASH-capable synchrocyclotron, setting the distal 90% of the Bragg peak around 35 mm away from the ultrasound array. This configuration allowed us to assess various total proton radiation doses, maintaining a consistent beam output of 21 pC/pulse. We also explored a spectrum of dose rates, from 15 Gy/s up to a FLASH rate of 48 Gy/s, by administering a set number of pulses. Furthermore, we implemented a three-dot scanning beam approach to observe the distinct movements of individual Bragg peaks using PAI. All these procedures utilized a proton beam energy of 180 MeV to achieve the maximum possible dose rate.

RESULTS:

Our findings indicate a strong linear relationship between protoacoustic signal amplitudes and delivered doses (R2 = 0.9997), with a consistent fit across different dose rates. The technique successfully provided 3D renderings of Bragg peaks at FLASH rates, validated through absolute Gamma index values.

CONCLUSIONS:

The protoacoustic system demonstrates effectiveness in 3D visualization and tracking of the Bragg peak during FLASH proton therapy, representing a notable advancement in proton therapy quality assurance. This method promises enhancements in protoacoustic image guidance and real-time dosimetry, paving the way for more accurate and effective treatments in ultra-high dose rate therapy environments.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Radiometría Límite: Humans Idioma: En Revista: Med Phys Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Radiometría Límite: Humans Idioma: En Revista: Med Phys Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos