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Insights On The Tunisian Prickly Pear Molasses As A Potential Antifibrotic And Antioxidant Candidate Against Lung Fibrosis.
Bahri, Sana; Bouazizi, Souhir; Nahdi, Afef; Mlika, Mona; Hamdi, Mokhtar; Jameleddine, Saloua.
Afiliación
  • Bahri S; University of Tunis El Manar Faculty of Medicine of Tunis, physiology, Beb saadoun, Tunis, TUNISIA.
  • Bouazizi S; University of Carthage, Biological and chemical engineering, centre urbain nord, Tunis, TUNISIA.
  • Nahdi A; University of Tunis El Manar Faculty of Medicine of Tunis, Histology, Beb saadoun, Tunis, TUNISIA.
  • Mlika M; University of Tunis El Manar Faculty of Medicine of Tunis, histopathology, Beb saadoun, Tunis, TUNISIA.
  • Hamdi M; University of Carthage, Biological and chemical engineering, centre urbain nord, Tunis, TUNISIA.
  • Jameleddine S; University of Tunis El Manar Faculty of Medicine of Tunis, physiology, Beb saadoun, Tunis, TUNISIA.
Chem Biodivers ; : e202401030, 2024 Jul 29.
Article en En | MEDLINE | ID: mdl-39073317
ABSTRACT
Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive interstitial disease leading to pulmonary damage and respiratory failure.  We aimed to investigate the effect of prickly pear molasses (PPM) on an experimental model of pulmonary fibrosis induced by bleomycin (BLM) in Wistar rat. Animals were divided into 5 groups the control group (G1), the BLM group (G2) and three groups (G3, G4, G5) receiving a single intra-tracheal injection of BLM (4 mg/kg) and PPM (at 2, 4.5 and10 %) that was introduced into the diet one week before BLM injection and continued for 3 weeks. Our phytochemical results revealed significant polyphenol and flavonoid content. LCMS analysis revealed the presence of Sinapinic acid, t-ferulic acid, t-cinnamic acid, Caffeic acid, gallic acid and vallinic acid among others. Our histological study revealed significant decrease in collagen deposition in the groups of rats treated with 4.5% and 10% molasses compared to BLM group. Oxidative stress in pulmonary tissues was investigated using catalase (CAT), superoxide dismutase (SOD), and malondialdehyde (MDA) assays. Treatment with PPM normalized the disturbance in the level of these oxidative markers in G3,G4, G5 compared to G2. In conclusion, PPM exhibit antifibrotic and antioxidant activities in BLM model of lung fibrosis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Chem Biodivers Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: Túnez Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Chem Biodivers Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: Túnez Pais de publicación: Suiza