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A comprehensive overview of the molecular features and therapeutic targets in BRAFV600E-mutant colorectal cancer.
Gu, Ruiqi; Fang, Hongsheng; Wang, Renjie; Dai, Weixing; Cai, Guoxiang.
Afiliación
  • Gu R; Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
  • Fang H; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
  • Wang R; Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
  • Dai W; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
  • Cai G; Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
Clin Transl Med ; 14(7): e1764, 2024 Jul.
Article en En | MEDLINE | ID: mdl-39073010
ABSTRACT
As one of the most prevalent digestive system tumours, colorectal cancer (CRC) poses a significant threat to global human health. With the emergence of immunotherapy and target therapy, the prognosis for the majority of CRC patients has notably improved. However, the subset of patients with BRAF exon 15 p.V600E mutation (BRAFV600E) has not experienced remarkable benefits from these therapeutic advancements. Hence, researchers have undertaken foundational investigations into the molecular pathology of this specific subtype and clinical effectiveness of diverse therapeutic drug combinations. This review comprehensively summarised the distinctive molecular features and recent clinical research advancements in BRAF-mutant CRC. To explore potential therapeutic targets, this article conducted a systematic review of ongoing clinical trials involving patients with BRAFV600E-mutant CRC.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Proteínas Proto-Oncogénicas B-raf / Mutación Límite: Humans Idioma: En Revista: Clin Transl Med Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Proteínas Proto-Oncogénicas B-raf / Mutación Límite: Humans Idioma: En Revista: Clin Transl Med Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos