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Posttransplantation cyclophosphamide mediates effective reconstitution of memory B cells after allogeneic hematopoietic cell transplantation.
Hayashi, Tetsuya; Nakashima, Yasuhiro; Takeda, Shinichi; Nishimoto, Mitsutaka; Okamura, Hiroshi; Takakuwa, Teruhito; Kuno, Masatomo; Makuuchi, Yosuke; Ido, Kentaro; Sakatoku, Kazuki; Horiuchi, Mirei; Koh, Hideo; Nakamae, Mika; Hino, Masayuki; Nakamae, Hirohisa.
Afiliación
  • Hayashi T; Department of Hematology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
  • Nakashima Y; Department of Hematology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
  • Takeda S; Department of Clinical Laboratory, Osaka Metropolitan University Hospital, Osaka, Japan.
  • Nishimoto M; Department of Hematology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
  • Okamura H; Department of Hematology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
  • Takakuwa T; Department of Laboratory Medicine and Medical Informatics, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
  • Kuno M; Department of Hematology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
  • Makuuchi Y; Department of Hematology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
  • Ido K; Department of Hematology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
  • Sakatoku K; Department of Hematology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
  • Horiuchi M; Department of Clinical Laboratory, Osaka Metropolitan University Hospital, Osaka, Japan.
  • Koh H; Department of Laboratory Medicine and Medical Informatics, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
  • Nakamae M; Department of Hematology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
  • Hino M; Department of Hematology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
  • Nakamae H; Department of Hematology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
Eur J Haematol ; 113(5): 651-663, 2024 Nov.
Article en En | MEDLINE | ID: mdl-39072897
ABSTRACT

OBJECTIVES:

Impaired B-cell reconstitution after allogeneic hematopoietic cell transplantation (allo-HCT) contributes to the pathogenesis of chronic graft-versus-host disease (cGVHD). Therefore, methods to consistently achieve effective B cell lymphogenesis are required. We assessed the long-term effects of posttransplantation cyclophosphamide (PTCy) use on immune reconstitution in clinical settings, an emerging strategy to suppress allogeneic immunological inflammation early after allo-HCT and prevent subsequent GVHD.

METHODS:

We comprehensively analyzed peripheral immune cell subsets and measured serum immunoglobulin G (IgG) or cytokine levels in 39 patients who survived for >1 year after allo-HCT.

RESULTS:

The absolute counts of B1 and IgM memory B cells were significantly lower in patients with severe cGVHD than in those without. The absolute count and percentage (among total CD19+ B cells) of switched memory B cells and serum IgG levels were significantly higher in patients transplanted with PTCy than in those transplanted with conventional GVHD prophylaxis. Interestingly, increased percentages of switched memory B cells and serum IgG levels were observed only in patients transplanted with PTCy and not in those transplanted with umbilical cord blood.

CONCLUSIONS:

PTCy administration can mediate favorable memory B-cell reconstitution long after allo-HCT and may therefore suppress cGVHD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trasplante Homólogo / Inmunoglobulina G / Trasplante de Células Madre Hematopoyéticas / Ciclofosfamida / Células B de Memoria / Enfermedad Injerto contra Huésped Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Eur J Haematol Asunto de la revista: HEMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trasplante Homólogo / Inmunoglobulina G / Trasplante de Células Madre Hematopoyéticas / Ciclofosfamida / Células B de Memoria / Enfermedad Injerto contra Huésped Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Eur J Haematol Asunto de la revista: HEMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido