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NIR-II AIE Luminogen-Based Erythrocyte-Like Nanoparticles with Granuloma-Targeting and Self-Oxygenation Characteristics for Combined Phototherapy of Tuberculosis.
Wang, Huanhuan; Li, Bin; Sun, Yan; Ma, Qiang; Feng, Yi; Jia, Yue; Wang, Wei; Su, Min; Liu, Xueting; Shu, Bowen; Zheng, Jundun; Sang, Shuo; Yan, Yan; Wu, Yanqiu; Zhang, Yunlong; Gao, Qiuxia; Li, Peiran; Wang, Jiamei; Ma, Fei; Li, Xiaoxue; Yan, Dingyuan; Wang, Dong; Zou, Xiaoming; Liao, Yuhui.
Afiliación
  • Wang H; The Seventh Affiliated Hospital, Southern Medical University, Foshan, Guangdong, 528200, China.
  • Li B; Institute for Engineering Medicine, Kunming Medical University, Kunming, Yunnan, 650500, China.
  • Sun Y; School of Inspection, Ningxia Medical University, Yinchuan, Ningxia, 750004, China.
  • Ma Q; Center for AIE Research, Shenzhen Key Laboratory of Polymer Science and Technology, Guangdong Research Center for Interfacial Engineering of Functional Materials, College of Materials Science and Engineering, Shenzhen University, Shenzhen, Guangdong, 518060, China.
  • Feng Y; The Seventh Affiliated Hospital, Southern Medical University, Foshan, Guangdong, 528200, China.
  • Jia Y; Molecular Diagnosis and Treatment Center for Infectious Diseases, Dermatology Hospital of Southern Medical University, Guangzhou, Guangdong, 516006, China.
  • Wang W; School of Inspection, Ningxia Medical University, Yinchuan, Ningxia, 750004, China.
  • Su M; Molecular Diagnosis and Treatment Center for Infectious Diseases, Dermatology Hospital of Southern Medical University, Guangzhou, Guangdong, 516006, China.
  • Liu X; School of Inspection, Ningxia Medical University, Yinchuan, Ningxia, 750004, China.
  • Shu B; School of Inspection, Ningxia Medical University, Yinchuan, Ningxia, 750004, China.
  • Zheng J; Molecular Diagnosis and Treatment Center for Infectious Diseases, Dermatology Hospital of Southern Medical University, Guangzhou, Guangdong, 516006, China.
  • Sang S; Molecular Diagnosis and Treatment Center for Infectious Diseases, Dermatology Hospital of Southern Medical University, Guangzhou, Guangdong, 516006, China.
  • Yan Y; School of Inspection, Ningxia Medical University, Yinchuan, Ningxia, 750004, China.
  • Wu Y; Molecular Diagnosis and Treatment Center for Infectious Diseases, Dermatology Hospital of Southern Medical University, Guangzhou, Guangdong, 516006, China.
  • Zhang Y; Molecular Diagnosis and Treatment Center for Infectious Diseases, Dermatology Hospital of Southern Medical University, Guangzhou, Guangdong, 516006, China.
  • Gao Q; Molecular Diagnosis and Treatment Center for Infectious Diseases, Dermatology Hospital of Southern Medical University, Guangzhou, Guangdong, 516006, China.
  • Li P; Institute for Engineering Medicine, Kunming Medical University, Kunming, Yunnan, 650500, China.
  • Wang J; Molecular Diagnosis and Treatment Center for Infectious Diseases, Dermatology Hospital of Southern Medical University, Guangzhou, Guangdong, 516006, China.
  • Ma F; Molecular Diagnosis and Treatment Center for Infectious Diseases, Dermatology Hospital of Southern Medical University, Guangzhou, Guangdong, 516006, China.
  • Li X; School of Inspection, Ningxia Medical University, Yinchuan, Ningxia, 750004, China.
  • Yan D; Molecular Diagnosis and Treatment Center for Infectious Diseases, Dermatology Hospital of Southern Medical University, Guangzhou, Guangdong, 516006, China.
  • Wang D; Center for AIE Research, Shenzhen Key Laboratory of Polymer Science and Technology, Guangdong Research Center for Interfacial Engineering of Functional Materials, College of Materials Science and Engineering, Shenzhen University, Shenzhen, Guangdong, 518060, China.
  • Zou X; Center for AIE Research, Shenzhen Key Laboratory of Polymer Science and Technology, Guangdong Research Center for Interfacial Engineering of Functional Materials, College of Materials Science and Engineering, Shenzhen University, Shenzhen, Guangdong, 518060, China.
  • Liao Y; The Seventh Affiliated Hospital, Southern Medical University, Foshan, Guangdong, 528200, China.
Adv Mater ; : e2406143, 2024 Jul 28.
Article en En | MEDLINE | ID: mdl-39072892
ABSTRACT
Tuberculosis, a fatal infectious disease caused by Mycobacterium tuberculosis (M.tb), is difficult to treat with antibiotics due to drug resistance and short drug half-life. Phototherapy represents a promising alternative to antibiotics in combating M.tb. Exploring an intelligent material allowing effective tuberculosis treatment is definitely appealing, yet a significantly challenging task. Herein, an all-in-one biomimetic therapeutic nanoparticle featured by aggregation-induced second near-infrared emission, granuloma-targeting, and self-oxygenation is constructed, which can serve for prominent fluorescence imaging-navigated combined phototherapy toward tuberculosis. After camouflaging the biomimetic erythrocyte membrane, the nanoparticles show significantly prolonged blood circulation and increased selective accumulation in tuberculosis granuloma. Upon laser irradiation, the loading photosensitizer of aggregation-induced emission photosensitizer elevates the production of reactive oxygen species (ROS), causing M.tb damage and death. The delivery of oxygen to relieve the hypoxic granuloma microenvironment supports ROS generation during photodynamic therapy. Meanwhile, the photothermal agent, Prussian blue nanoparticles, plays the role of good photothermal killing effect on M.tb. Moreover, the growth and proliferation of granuloma and M.tb colonies are effectively inhibited in the nanoparticle-treated tuberculous granuloma model mice, suggesting the combined therapeutic effects of enhancing photodynamic therapy and photothermal therapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Adv Mater Asunto de la revista: BIOFISICA / QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Adv Mater Asunto de la revista: BIOFISICA / QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania