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Transformation of spatial representations along hippocampal circuits.
Gandit, Bérénice; Posani, Lorenzo; Zhang, Chun-Lei; Saha, Soham; Ortiz, Cantin; Allegra, Manuela; Schmidt-Hieber, Christoph.
Afiliación
  • Gandit B; Institut Pasteur, Université Paris Cité, Neural Circuits for Spatial Navigation and Memory, Department of Neuroscience, F-75015 Paris, France.
  • Posani L; Sorbonne Université, Collège Doctoral, F-75005 Paris, France.
  • Zhang CL; Center for Theoretical Neuroscience, Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA.
  • Saha S; Institut Pasteur, Université Paris Cité, Neural Circuits for Spatial Navigation and Memory, Department of Neuroscience, F-75015 Paris, France.
  • Ortiz C; Institut Pasteur, Université Paris Cité, Neural Circuits for Spatial Navigation and Memory, Department of Neuroscience, F-75015 Paris, France.
  • Allegra M; Institut Pasteur, Université Paris Cité, Neural Circuits for Spatial Navigation and Memory, Department of Neuroscience, F-75015 Paris, France.
  • Schmidt-Hieber C; Sorbonne Université, Collège Doctoral, F-75005 Paris, France.
iScience ; 27(7): 110361, 2024 Jul 19.
Article en En | MEDLINE | ID: mdl-39071886
ABSTRACT
The hippocampus is thought to provide the brain with a cognitive map of the external world by processing various types of spatial information. To understand how essential spatial variables such as direction, position, and distance are transformed along its circuits to construct this global map, we perform single-photon widefield microendoscope calcium imaging in the dentate gyrus and CA3 of mice freely navigating along a narrow corridor. We find that spatial activity maps in the dentate gyrus, but not in CA3, are correlated after aligning them to the running directions, suggesting that they represent the distance traveled along the track in egocentric coordinates. Together with population activity decoding, our data suggest that while spatial representations in the dentate gyrus and CA3 are anchored in both egocentric and allocentric coordinates, egocentric distance coding is more prevalent in the dentate gyrus than in CA3, providing insights into the assembly of the cognitive map.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: IScience Año: 2024 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: IScience Año: 2024 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos