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Acacia saligna extract alleviates quetiapine-induced sexual toxicity in male albino rats: Insights from UPLC-MS/MS metabolite profiling, structural and PI3K/NF-κB pathway assessments.
Yousof, Shimaa Mohammad; Shehata, Shaimaa A; Ismail, Ezzat A; Abd El-Moneam, Samar M; Mansour, Basma S A; Farag, Mohamed A; Elshamy, Abdelsamed I; El-Nasser G El Gendy, Abd; Serag, Ahmed; Abd El-Fadeal, Noha M; Abdel-Karim, Rehab Ibrahim; Mostafa, Mostafa M; El-Sheikh, Dina H; Zayed, Mohamed A.
Afiliación
  • Yousof SM; Medical Physiology Department, Faculty of Medicine, King Abdulaziz University, Rabigh Branch, 21589, Saudi Arabia.
  • Shehata SA; Medical Physiology Department, Faculty of Medicine, Suez Canal University, Ismailia 41522, Egypt.
  • Ismail EA; Neuroscience and Geroscience Unit, King Fahad Research Centre, King Abdulaziz University, KSA.
  • Abd El-Moneam SM; Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine- Suez Canal University, Ismailia, 41522, Egypt.
  • Mansour BSA; Urology Department, Faculty of Medicine, Suez Canal University, Ismailia, 41522, Egypt.
  • Farag MA; Human Anatomy and Embryology, Faculty of Medicine, Suez Canal University, Ismailia, 41522, Egypt.
  • Elshamy AI; Human Anatomy and Embryology, Faculty of Medicine, Suez Canal University, Ismailia, 41522, Egypt.
  • El-Nasser G El Gendy A; Pharmacognosy Department, College of Pharmacy, Cairo University, Kasr el Aini, Giza 12613, Egypt.
  • Serag A; Department of Natural Compounds Chemistry, National Research Center, Dokki, Giza 12622, Egypt.
  • Abd El-Fadeal NM; Medicinal and Aromatic Plants Research Department, National Research Centre, 33 El Bohouth St., Dokki, Giza, 12622, Egypt.
  • Abdel-Karim RI; Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo, 11751, Egypt.
  • Mostafa MM; Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Suez Canal University, Ismailia, 41522, Egypt.
  • El-Sheikh DH; Biochemistry Department, Ibn Sina National College for Medical Studies, Jeddah, 22421, Saudi Arabia.
  • Zayed MA; Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine- Suez Canal University, Ismailia, 41522, Egypt.
Heliyon ; 10(13): e33993, 2024 Jul 15.
Article en En | MEDLINE | ID: mdl-39071580
ABSTRACT

Background:

Quetiapine (QET) abuse has increased due to its anxiolytic and hedonic effects, necessitating protective adjunct treatments. Acacia saligna (A. saligna) flowers, used in traditional medicine, have potential health benefits.

Aim:

To investigate the protective role of A. saligna flower extract against QET-induced sexual toxicity, and to elucidate the possible underlying mechanisms through metabolomic and physiological studies.

Methods:

A. saligna extract was subjected to metabolite profiling via High-Resolution Ultra-Performance Liquid Chromatography-Mass Spectrometry (UPLC-ESI-qTOF-MS). Forty-eight adult male albino rats were assigned into six groups for 30 days. The intracavernosal pressure (ICP), semen, biochemical, hormonal, histological, genetic and Western blot (WB) analyses were determined.

Results:

A. saligna extract is rich in phenolic compounds, flavonoids, tannins, and unsaturated fatty acids. QET significantly decreased ICP and negatively affected semen parameters. A. saligna mitigated decreased sperm motility and ameliorated overexpressed proinflammatory genes in QET-55 group. A. saligna ameliorated the reduction of the antioxidant biomarkers, testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH), concurrent with downregulation of the nuclear factor kappa B (NF-κB) protein. A. saligna counteracted the disrupted testicular and prostatic structures revealed by histological examination.

Conclusion:

The extract from A. saligna, which contains a high concentration of antioxidants and anti-inflammatory chemicals, effectively mitigates sexual toxicity caused by QET. This study provided the first known explanation of the hypothesized processes behind the protective properties of A. saligna through biological, biochemical, and histological parameters. The results emphasize the potential of A. saligna as a safeguarding agent against drug-induced sexual toxicity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Heliyon Año: 2024 Tipo del documento: Article País de afiliación: Arabia Saudita Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Heliyon Año: 2024 Tipo del documento: Article País de afiliación: Arabia Saudita Pais de publicación: Reino Unido