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S100A10 promotes cancer metastasis via recruitment of MDSCs within the lungs.
Li, Juan; Zhou, Can; Gao, Xiaoqian; Tan, Tan; Zhang, Miao; Li, Yazhao; Chen, He; Wang, Ruiqi; Wang, Bo; Liu, Jie; Liu, Peijun.
Afiliación
  • Li J; Center for Translational Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
  • Zhou C; Key Laboratory for Tumor Precision Medicine of Shaanxi Province, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
  • Gao X; Department of Breast Surgery, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
  • Tan T; Center for Translational Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
  • Zhang M; Key Laboratory for Tumor Precision Medicine of Shaanxi Province, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
  • Li Y; Center for Precision Medicine, the First People's Hospital of Chenzhou, Chenzhou, Hunan, China.
  • Chen H; Center for Translational Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
  • Wang R; Key Laboratory for Tumor Precision Medicine of Shaanxi Province, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
  • Wang B; Center for Translational Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
  • Liu J; Key Laboratory for Tumor Precision Medicine of Shaanxi Province, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
  • Liu P; Center for Translational Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Oncoimmunology ; 13(1): 2381803, 2024.
Article en En | MEDLINE | ID: mdl-39071160
ABSTRACT
Tumor-derived exosomes bind to organ resident cells, activating S100 molecules during the remodeling of the local immune microenvironment. However, little is known regarding how organ resident cell S100A10 mediates cancer metastatic progression. Here, we provided evidence that S100A10 plays an important role in regulating the lung immune microenvironment and cancer metastasis. S100A10-deficient mice reduced cancer metastasis in the lung. Furthermore, the activation of S100A10 within lung fibroblasts via tumor-derived exosomes increased the expression of CXCL1 and CXCL8 chemokines, accompanied by the myeloid-derived suppressor cells (MDSCs) recruitment. S100A10 inhibitors such as 1-Substituted-4-Aroyl-3-hydroxy-5-Phenyl-1 H-5-pyrrol-2(5 H)-ones inhibit lung metastasis in vivo. Our findings highlight the crucial role of S100A10 in driving MDSC recruitment in order to remodel the lung immune microenvironment and provide potential therapeutic targets to block cancer metastasis to the lung.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas S100 / Microambiente Tumoral / Células Supresoras de Origen Mieloide / Neoplasias Pulmonares Límite: Animals / Humans Idioma: En Revista: Oncoimmunology Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas S100 / Microambiente Tumoral / Células Supresoras de Origen Mieloide / Neoplasias Pulmonares Límite: Animals / Humans Idioma: En Revista: Oncoimmunology Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos