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Aspergillus terreus pulmonary infection in a patient with late-onset combined immunodeficiency: a case report with literature review.
Lodha, Naman; Shankar Meena, Durga; Bhellum, Pyrus; R, Neetha T; C, Sadiya F; Khatod, Yash; Jain, Vidhi; Kumar, Deepak; Yadav, Taruna.
Afiliación
  • Lodha N; Department of Internal Medicine, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
  • Shankar Meena D; Division of Infectious Diseases, Department of Internal Medicine, All India Institute of Medical Sciences, Jodhpur, Rajasthan 342005, India.
  • Bhellum P; Department of Internal Medicine, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
  • R NT; Division of Infectious Diseases, Department of Internal Medicine, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
  • C SF; Department of Microbiology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
  • Khatod Y; Division of Infectious Diseases, Department of Internal Medicine, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
  • Jain V; Department of Microbiology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
  • Kumar D; Division of Infectious Diseases, Department of Internal Medicine, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
  • Yadav T; Department of Diagnostic and Interventional Radiology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
Ther Adv Infect Dis ; 11: 20499361241265932, 2024.
Article en En | MEDLINE | ID: mdl-39070699
ABSTRACT
Common variable immunodeficiency (CVID) is the most common humoral immune deficiency in adults, characterized by recurrent sinopulmonary bacterial infections. Invasive fungal infections are rarely associated with CVID. Late-onset combined immunodeficiency (LOCID) is a recently recognized variant of CVID with low CD4 counts and immunoglobulins deficiency. The current study reveals the first documented case of invasive pulmonary aspergillosis (Aspergillus terreus) in a patient with LOCID. A 52-year-old female with a recurrent history of sinopulmonary infections presented with acute onset fever and shortness of breath. Blood culture and bronchoalveolar lavage culture grew A. terreus. Further evaluation revealed low immunoglobulins (IgG, IgM and IgA). Moreover, she also had low CD4 counts (<200 cells/µL). The patient was successfully treated with voriconazole and immunoglobulin therapy. Finally, the study discusses LOCID as a potential risk factor for invasive fungal infections, which can be easily overlooked and cause poor outcomes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Ther Adv Infect Dis Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Ther Adv Infect Dis Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Reino Unido