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Gemcitabine-Induced Thrombotic Microangiopathy in a Patient With Cholangiocarcinoma: An Atypical Case.
Anil, Vishwanath; Alhujaily, Ensaf; Grover, Deeksha; Santos, Jolina P; Kanugula, Ashok Kumar; Suleiman, Moyosore; Singh, Sonu.
Afiliación
  • Anil V; Internal Medicine, Wellstar Spalding Medical Center, Griffin, USA.
  • Alhujaily E; Internal Medicine, Wellstar Spalding Medical Center, Griffin, USA.
  • Grover D; Internal Medicine, Wellstar Spalding Medical Center, Griffin, USA.
  • Santos JP; Nephrology, Wellstar Spalding Medical Center, Griffin, USA.
  • Kanugula AK; Internal Medicine, Wellstar Spalding Medical Center, Griffin, USA.
  • Suleiman M; Hematology and Medical Oncology, Wellstar Spalding Medical Center, Griffin, USA.
  • Singh S; Nephrology, Wellstar Spalding Medical Center, Griffin, USA.
Cureus ; 16(6): e63385, 2024 Jun.
Article en En | MEDLINE | ID: mdl-39070506
ABSTRACT
Gemcitabine-induced thrombotic microangiopathy (GITMA) is a rare but severe complication seen in cancer patients on gemcitabine therapy. This case report describes a 45-year-old female with metastatic cholangiocarcinoma on gemcitabine-capecitabine who developed acute kidney injury and hypertension without typical hematologic signs of thrombotic microangiopathy (TMA). Despite initial management targeting hypertensive urgency and acute kidney injury, renal function continued to decline and progressed to end-stage renal disease requiring hemodialysis. Laboratory tests revealed TMA features such as elevated lactate dehydrogenase (LDH), decreased haptoglobin, and schistocytes. Renal biopsy confirmed TMA with chronic features. This case highlights the challenge of diagnosing drug-induced TMA without typical hematologic findings.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cureus Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cureus Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos